Nanoscale Coordination Polymers for Combined Chemotherapy and Photodynamic Therapy of Metastatic Cancer

Combination therapy enhances anticancer efficacy through synergistic effects of different drugs/modalities and can potentially address the challenges in the treatment of metastatic diseases. Here we report the design of carb/pyro nanoscale coordination polymer nanoparticles that carry carboplatin (c...

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Veröffentlicht in:	Bioconjugate chemistry 2021-11, Vol.32 (11), p.2318-2326
Hauptverfasser:	Li, Youyou, Han, Wenbo, He, Chunbai, Jiang, Xiaomin, Fan, Yingjie, Lin, Wenbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Breast cancer Calreticulin Cancer therapies Carboplatin Carboplatin - administration & dosage Carboplatin - chemistry Carboplatin - pharmacology Carboplatin - therapeutic use Cell Line, Tumor Chemotherapy Colorectal cancer Colorectal carcinoma Coordination polymers Female Humans Intravenous administration Irradiation Light irradiation Metastases Metastasis Mice Mice, Inbred BALB C Nanoparticles Nanoparticles - chemistry Neoplasm Metastasis Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Polymers Polymers - chemistry Radiation Reactive oxygen species Reactive Oxygen Species - metabolism Synergistic effect Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - pathology Tumors
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