Association of ABCC2 Haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients

Mycophenolic acid exhibits significant interpatient pharmacokinetic variability attributed to factors including race, sex, concurrent medications, and enterohepatic circulation of the mycophenolic acid glucuronide metabolite to mycophenolic acid. This conversion by enterohepatic circulation is media...

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Veröffentlicht in:	Journal of clinical pharmacology 2021-12, Vol.61 (12), p.1592-1605
Hauptverfasser:	Brazeau, Daniel, Meaney, Calvin J., Consiglio, Joseph D., Wilding, Gregory E., Cooper, Louise M., Venuto, Rocco C., Tornatore, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCC2 haplotypes Acids Adult Area Under Curve Calcineurin calcineurin inhibitor Calcineurin inhibitors Calcineurin Inhibitors - administration & dosage Calcineurin Inhibitors - pharmacology Cross-Sectional Studies Cyclosporins enterohepatic circulation Enterohepatic Circulation - physiology Female Genotypes Haplotypes Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - pharmacology Kidney Transplantation Kidney transplants Male Middle Aged Multidrug resistance Multidrug Resistance-Associated Protein 2 - genetics Mycophenolic acid Mycophenolic Acid - pharmacokinetics Pharmacokinetics Phenotypes Prospective Studies Tacrolimus transporters
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