Optimizing Epitope Conformational Ensembles Using α‑Synuclein Cyclic Peptide “Glycindel” Scaffolds: A Customized Immunogen Method for Generating Oligomer-Selective Antibodies for Parkinson’s Disease

Effectively presenting epitopes on immunogens, in order to raise conformationally selective antibodies through active immunization, is a central problem in treating protein misfolding diseases, particularly neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease. We seek to sel...

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Veröffentlicht in:	ACS chemical neuroscience 2022-08, Vol.13 (15), p.2261-2280
Hauptverfasser:	Hsueh, Shawn C. C., Aina, Adekunle, Roman, Andrei Yu, Cashman, Neil R., Peng, Xubiao, Plotkin, Steven S.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Antibodies Epitopes Humans Parkinson Disease - metabolism Peptides, Cyclic Protein Conformation Solvents
Online-Zugang:	Volltext
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