Disruption of Lipid Raft Microdomains, Regulation of CD38, TP53, and MYC Signaling, and Induction of Apoptosis by Lomitapide in Multiple Myeloma Cells

Background/Aim: Multiple myeloma (MM) is characterized by accumulation of a malignant clone of plasma cells in the bone marrow. Curative treatments are not yet available. Therefore, we undertook a drug repurposing approach to identify possible candidates from a chemical library of 1,230 FDA-approved...

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Veröffentlicht in:	Cancer genomics & proteomics 2022-09, Vol.19 (5), p.540-555
Hauptverfasser:	SAEED, MOHAMED E. M., BOULOS, JOELLE C., MÜCKLICH, SABRINA B., LEICH, ELLEN, CHATTERJEE, MANIK, KLAUCK, SABINE M., EFFERTH, THOMAS
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biomarkers Bone marrow Bruton's tyrosine kinase c-Myc protein CD38 antigen Cell cycle Chemical compounds Confocal microscopy Crosstalk Cytotoxicity Deregulation Disruption DNA microarrays Drug development Drug screening Flow cytometry Gene expression Genes Hybridization Kinases Lipid rafts Lipids Microscopy Multiple myeloma Myc protein p53 Protein Pharmacology Plasma cells Poly(ADP-ribose) polymerase Protein-tyrosine kinase Screening Toxicity Tumor suppressor genes Tumors Tyrosine Western blotting
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