Shelterin is a dimeric complex with extensive structural heterogeneity

Human shelterin is a six-subunit complex—composed of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1—that binds telomeres, protects them from the DNA-damage response, and regulates the maintenance of telomeric DNA. Although high-resolution structures have been generated of the individual structured domains w...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-08, Vol.119 (31), p.1-e2201662119
Hauptverfasser:	Zinder, John C., Olinares, Paul Dominic B., Svetlov, Vladimir, Bush, Martin W., Nudler, Evgeny, Chait, Brian T., Walz, Thomas, de Lange, Titia
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biological Sciences Crosslinking Deoxyribonucleic acid Dimers DNA DNA damage Domains Electron microscopy Heterogeneity Mass spectrometry Mass spectroscopy Oligonucleotides Oligosaccharides Photometry Rap1 protein Scientific imaging Spectroscopy Stoichiometry Substrates Telomere-binding protein Telomeres TRF2 protein
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