Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant contains extensive sequence changes relative to the earlier-arising B.1, B.1.1, and Delta SARS-CoV-2 variants that have unknown effects on viral infectivity and response to existing vaccines. Using SARS-CoV-2 virus-like...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-08, Vol.119 (31), p.1-7
Hauptverfasser:	Syed, Abdullah M., Ciling, Alison, Taha, Taha Y., Chen, Irene P., Khalid, Mir M., Sreekumar, Bharath, Chen, Pei-Yi, Kumar, G. Renuka, Suryawanshi, Rahul, Silva, Ines, Milbes, Bilal, Kojima, Noah, Hess, Victoria, Shacreaw, Maria, Lopez, Lauren, Brobeck, Matthew, Turner, Fred, Spraggon, Lee, Tabata, Takako, Ott, Melanie, Doudna, Jennifer A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisera Assembly BASIC BIOLOGICAL SCIENCES Biological Sciences Coronaviruses COVID-19 Infectivity Monoclonal antibodies Mutation Neutralization Proteins Robustness Science & Technology - Other Topics Severe acute respiratory syndrome coronavirus 2 Spike protein Structural proteins Vaccines Viral diseases Virus-like particles Viruses
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