The role of treatment with plasma exchange therapy in two pediatric toxic epidermal necrolysis cases related to COVID‐19
Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life‐threatening mucocutaneous reactions characterized by necrosis and detachment of the epidermis. Drugs and bacterial or viral infections are the most common causes of SJS/TEN. Although cases of SJS/TEN have been reported afte...
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| Veröffentlicht in: | Journal of clinical apheresis 2022-10, Vol.37 (5), p.516-521 |
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| container_title | Journal of clinical apheresis |
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| creator | Varol, Fatih Can, Yasar Yusuf Sahin, Ebru Durak, Cansu Kilic, Aziz Sahin, Ceyhan Gursoy, Fatima Akin, Tugba |
| description | Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life‐threatening mucocutaneous reactions characterized by necrosis and detachment of the epidermis. Drugs and bacterial or viral infections are the most common causes of SJS/TEN. Although cases of SJS/TEN have been reported after hydroxychloroquine, vaccine (mRNA [Biontech], and inactivated vaccine [Sinovac]) administration and during the clinical course of active Coronavirus disease 2019 (COVID‐19), limited data is indicating the COVID‐19 disease as a triggering factor. Also, there are no pediatric cases of SJS/TEN associated with COVID‐19 in the literature. Herein we reported two pediatric cases with a diagnosis of TEN related to COVID‐19. Therapeutic plasma exchange therapy was applied to both of our patients. Although there are a few adult cases in the literature, our article is the first pediatric case report about patients diagnosed with TEN related to COVID‐19 and successfully treated with plasma exchange. |
| doi_str_mv | 10.1002/jca.21997 |
| format | Article |
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Drugs and bacterial or viral infections are the most common causes of SJS/TEN. Although cases of SJS/TEN have been reported after hydroxychloroquine, vaccine (mRNA [Biontech], and inactivated vaccine [Sinovac]) administration and during the clinical course of active Coronavirus disease 2019 (COVID‐19), limited data is indicating the COVID‐19 disease as a triggering factor. Also, there are no pediatric cases of SJS/TEN associated with COVID‐19 in the literature. Herein we reported two pediatric cases with a diagnosis of TEN related to COVID‐19. Therapeutic plasma exchange therapy was applied to both of our patients. 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| subjects | Apheresis Case Report Case Reports COVID-19 plasma exchange Skin diseases toxic epidermal necrolysis |
| title | The role of treatment with plasma exchange therapy in two pediatric toxic epidermal necrolysis cases related to COVID‐19 |
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