The suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1

Severe COVID‐19 disease is associated with thrombotic complications and extensive fibrin deposition. This study investigates whether the hemostatic complications in COVID‐19 disease arise due to dysregulation of the fibrinolytic system. This prospective study analyzed fibrinolytic profiles of 113 pa...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2022-10, Vol.20 (10), p.2394-2406
Hauptverfasser:	Whyte, Claire S., Simpson, Megan, Morrow, Gael B., Wallace, Carol A., Mentzer, Alexander J., Knight, Julian C., Shapiro, Susan, Curry, Nicola, Bagot, Catherine N., Watson, Henry, Cooper, Jamie G., Mutch, Nicola J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Carboxypeptidase B2 Chromogenic Compounds Confocal microscopy COVID-19 COVID-19 Drug Treatment Disease Enzyme-linked immunosorbent assay Fibrin Fibrinolysin - pharmacology Fibrinolysis Hemostatics - pharmacology Humans Lysis Original PAI‐1 Plasmin Plasminogen Activator Inhibitor 1 Plasminogen activator inhibitors Prospective Studies Respiration Respiratory diseases t-Plasminogen activator Tenecteplase Thrombin Thrombosis - drug therapy Tissue Plasminogen Activator - pharmacology Tissue polypeptide antigen TPA Vitronectin
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