Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2
The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were treated via the oral route with rutin and quercetin (50 mg/kg) either alone or in combination every other day for...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2022-07, Vol.2022, p.2710607-19 |
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| creator | Ahmed, Osama M. Elkomy, Mohammed H. Fahim, Hanaa I. Ashour, Mohamed B. Naguib, Ibrahim A. Alghamdi, Badrah S. Mahmoud, Heba Uallah R. Ahmed, Noha A. |
| description | The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were treated via the oral route with rutin and quercetin (50 mg/kg) either alone or in combination every other day for five weeks concomitant with receiving intraperitoneal DXR (2 mg/kg) two times a week for five successive weeks. Quercetin, rutin, and their combination significantly improved the deteriorated serum AST, ALT, and ALP activities and total bilirubin level, as well as albumin, AFP, and CA 19.9 levels in DXR-injected rats. Treatments of the DXR-injected group with quercetin and rutin prevented the elevation in liver lipid peroxidation and the reduction in superoxide dismutase, glutathione-S-transferase and glutathione peroxidase activities, and glutathione content. Treatments with quercetin and rutin significantly repressed the elevated expression of liver p53 and TNF-α and enhanced Nrf2 expression. Furthermore, the treatments significantly reduced DXR-induced liver histological changes. In conclusion, rutin and quercetin either alone or in combination may have potential preventive effects against DXR-induced hepatotoxicity through inhibiting oxidative stress, inflammation, and apoptosis as well as modulating the Nrf2 expression. |
| doi_str_mv | 10.1155/2022/2710607 |
| format | Article |
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In this study, male Wistar rats were treated via the oral route with rutin and quercetin (50 mg/kg) either alone or in combination every other day for five weeks concomitant with receiving intraperitoneal DXR (2 mg/kg) two times a week for five successive weeks. Quercetin, rutin, and their combination significantly improved the deteriorated serum AST, ALT, and ALP activities and total bilirubin level, as well as albumin, AFP, and CA 19.9 levels in DXR-injected rats. Treatments of the DXR-injected group with quercetin and rutin prevented the elevation in liver lipid peroxidation and the reduction in superoxide dismutase, glutathione-S-transferase and glutathione peroxidase activities, and glutathione content. Treatments with quercetin and rutin significantly repressed the elevated expression of liver p53 and TNF-α and enhanced Nrf2 expression. Furthermore, the treatments significantly reduced DXR-induced liver histological changes. In conclusion, rutin and quercetin either alone or in combination may have potential preventive effects against DXR-induced hepatotoxicity through inhibiting oxidative stress, inflammation, and apoptosis as well as modulating the Nrf2 expression.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2022/2710607</identifier><identifier>PMID: 35936216</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Animals ; Antihypertensives ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Apoptosis ; Cancer therapies ; Doxorubicin - toxicity ; Drug dosages ; Flavonoids ; Glutathione - metabolism ; Hepatitis - metabolism ; Inflammation ; Inflammation - pathology ; Liver ; Liver - metabolism ; Male ; NF-E2-Related Factor 2 - metabolism ; Oral administration ; Oxidative Stress ; Quercetin - pharmacology ; Quercetin - therapeutic use ; Radiation ; Rats ; Rats, Wistar ; Rutin - pharmacology ; Rutin - therapeutic use</subject><ispartof>Oxidative medicine and cellular longevity, 2022-07, Vol.2022, p.2710607-19</ispartof><rights>Copyright © 2022 Osama M. Ahmed et al.</rights><rights>Copyright © 2022 Osama M. Ahmed et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Osama M. Ahmed et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-8dedb239ce1e6f1eb60fafa29071148b9ae8950a83e19c4ec7239255d3919aad3</citedby><cites>FETCH-LOGICAL-c378t-8dedb239ce1e6f1eb60fafa29071148b9ae8950a83e19c4ec7239255d3919aad3</cites><orcidid>0000-0001-8380-8336 ; 0000-0002-5923-1466 ; 0000-0002-5772-6326 ; 0000-0001-9425-8288 ; 0000-0002-9411-3609 ; 0000-0003-4083-6024 ; 0000-0002-5080-0933 ; 0000-0003-3781-9709</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348941/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348941/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35936216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hussain, Tarique</contributor><contributor>Tarique Hussain</contributor><creatorcontrib>Ahmed, Osama M.</creatorcontrib><creatorcontrib>Elkomy, Mohammed H.</creatorcontrib><creatorcontrib>Fahim, Hanaa I.</creatorcontrib><creatorcontrib>Ashour, Mohamed B.</creatorcontrib><creatorcontrib>Naguib, Ibrahim A.</creatorcontrib><creatorcontrib>Alghamdi, Badrah S.</creatorcontrib><creatorcontrib>Mahmoud, Heba Uallah R.</creatorcontrib><creatorcontrib>Ahmed, Noha A.</creatorcontrib><title>Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. 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In conclusion, rutin and quercetin either alone or in combination may have potential preventive effects against DXR-induced hepatotoxicity through inhibiting oxidative stress, inflammation, and apoptosis as well as modulating the Nrf2 expression.</description><subject>Animals</subject><subject>Antihypertensives</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Doxorubicin - toxicity</subject><subject>Drug dosages</subject><subject>Flavonoids</subject><subject>Glutathione - metabolism</subject><subject>Hepatitis - metabolism</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Oral administration</subject><subject>Oxidative Stress</subject><subject>Quercetin - pharmacology</subject><subject>Quercetin - therapeutic use</subject><subject>Radiation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rutin - pharmacology</subject><subject>Rutin - therapeutic use</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1vEzEYhC0EoqVw44wscSRL_bFfviBVoaWRAhUliKPltd8lrhI72N40-Tn80zpKGpULJ489j8YjDUJvKflIaVWdM8LYOWsoqUnzDJ1SUbKCCFE-P2pCTtCrGO8IqTkr6Ut0wivBa0brU_T3dkjWYeUM_j5A0LC7jf3gEgT82W98GDqrrSsmzgwaDJ7adXZmfpNf0xZn-peNSQV8q1LEa6vwbA424K_eDAuVfNjiy74HnU3v8MT1C7VcqmS9G-GbjTVZrgH_SAFiHOGLlV8lH22Wu0rfQs9eoxe9WkR4czjP0M-ry9n4upjefJmML6aF5k2bitaA6RgXGijUPYWuJr3qFROkobRsO6GgFRVRLQcqdAm6yTCrKsMFFUoZfoY-7XNXQ7cEo8GloBZyFexSha30ysp_HWfn8rdfS8HLVpQ0B7w_BAT_Z4CY5J0fgsudJauFqMpco87UaE_p4GMM0B9_oETuBpW7QeVh0Iy_e9rqCD8umIEPe2BunVH39v9xD8Ajq4c</recordid><startdate>20220727</startdate><enddate>20220727</enddate><creator>Ahmed, Osama M.</creator><creator>Elkomy, Mohammed H.</creator><creator>Fahim, Hanaa I.</creator><creator>Ashour, Mohamed B.</creator><creator>Naguib, Ibrahim A.</creator><creator>Alghamdi, Badrah S.</creator><creator>Mahmoud, Heba Uallah R.</creator><creator>Ahmed, Noha A.</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8380-8336</orcidid><orcidid>https://orcid.org/0000-0002-5923-1466</orcidid><orcidid>https://orcid.org/0000-0002-5772-6326</orcidid><orcidid>https://orcid.org/0000-0001-9425-8288</orcidid><orcidid>https://orcid.org/0000-0002-9411-3609</orcidid><orcidid>https://orcid.org/0000-0003-4083-6024</orcidid><orcidid>https://orcid.org/0000-0002-5080-0933</orcidid><orcidid>https://orcid.org/0000-0003-3781-9709</orcidid></search><sort><creationdate>20220727</creationdate><title>Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2</title><author>Ahmed, Osama M. ; Elkomy, Mohammed H. ; Fahim, Hanaa I. ; Ashour, Mohamed B. ; Naguib, Ibrahim A. ; Alghamdi, Badrah S. ; Mahmoud, Heba Uallah R. ; Ahmed, Noha A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-8dedb239ce1e6f1eb60fafa29071148b9ae8950a83e19c4ec7239255d3919aad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Antihypertensives</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Doxorubicin - toxicity</topic><topic>Drug dosages</topic><topic>Flavonoids</topic><topic>Glutathione - metabolism</topic><topic>Hepatitis - metabolism</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Oral administration</topic><topic>Oxidative Stress</topic><topic>Quercetin - pharmacology</topic><topic>Quercetin - therapeutic use</topic><topic>Radiation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rutin - pharmacology</topic><topic>Rutin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Osama M.</creatorcontrib><creatorcontrib>Elkomy, Mohammed H.</creatorcontrib><creatorcontrib>Fahim, Hanaa I.</creatorcontrib><creatorcontrib>Ashour, Mohamed B.</creatorcontrib><creatorcontrib>Naguib, Ibrahim A.</creatorcontrib><creatorcontrib>Alghamdi, Badrah S.</creatorcontrib><creatorcontrib>Mahmoud, Heba Uallah R.</creatorcontrib><creatorcontrib>Ahmed, Noha A.</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Osama M.</au><au>Elkomy, Mohammed H.</au><au>Fahim, Hanaa I.</au><au>Ashour, Mohamed B.</au><au>Naguib, Ibrahim A.</au><au>Alghamdi, Badrah S.</au><au>Mahmoud, Heba Uallah R.</au><au>Ahmed, Noha A.</au><au>Hussain, Tarique</au><au>Tarique Hussain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2022-07-27</date><risdate>2022</risdate><volume>2022</volume><spage>2710607</spage><epage>19</epage><pages>2710607-19</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were treated via the oral route with rutin and quercetin (50 mg/kg) either alone or in combination every other day for five weeks concomitant with receiving intraperitoneal DXR (2 mg/kg) two times a week for five successive weeks. Quercetin, rutin, and their combination significantly improved the deteriorated serum AST, ALT, and ALP activities and total bilirubin level, as well as albumin, AFP, and CA 19.9 levels in DXR-injected rats. Treatments of the DXR-injected group with quercetin and rutin prevented the elevation in liver lipid peroxidation and the reduction in superoxide dismutase, glutathione-S-transferase and glutathione peroxidase activities, and glutathione content. Treatments with quercetin and rutin significantly repressed the elevated expression of liver p53 and TNF-α and enhanced Nrf2 expression. Furthermore, the treatments significantly reduced DXR-induced liver histological changes. 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| ispartof | Oxidative medicine and cellular longevity, 2022-07, Vol.2022, p.2710607-19 |
| issn | 1942-0900 1942-0994 |
| language | eng |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antihypertensives Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Apoptosis Cancer therapies Doxorubicin - toxicity Drug dosages Flavonoids Glutathione - metabolism Hepatitis - metabolism Inflammation Inflammation - pathology Liver Liver - metabolism Male NF-E2-Related Factor 2 - metabolism Oral administration Oxidative Stress Quercetin - pharmacology Quercetin - therapeutic use Radiation Rats Rats, Wistar Rutin - pharmacology Rutin - therapeutic use |
| title | Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2 |
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