Silencing TUFM Inhibits Development of Monocrotaline-Induced Pulmonary Hypertension by Regulating Mitochondrial Autophagy via AMPK/mTOR Signal Pathway

Pulmonary arterial hypertension (PAH) is an extremely malignant cardiovascular disease which mainly involves the uncontrollable proliferation of the pulmonary arterial smooth muscular cells (PASMCs). Recent studies have confirmed that mitochondria play an important role in the pathogenesis of pulmon...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022-07, Vol.2022, p.1-16
Hauptverfasser:	Wei, Ruyuan, Lv, Xin, Fang, Changcun, Liu, Chuanzhen, Ma, Zengshan, Liu, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Autophagy Biosynthesis Catheters Experiments Hemodynamics Hypoxia Laboratory animals Metabolism Mitochondria Ostomy Oxidative stress Pathogenesis Phosphorylation Proteins Pulmonary arteries Pulmonary hypertension Quality control Veins & arteries
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