Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways

Inflammation and apoptosis are main pathological processes that lead to the development of cardiac hypertrophy. Lupeol, a natural triterpenoid, has shown anti-inflammatory and anti-apoptotic activities as well as potential protective effects on cardiovascular diseases. In this study we investigated...

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Veröffentlicht in:	Acta pharmacologica Sinica 2022-08, Vol.43 (8), p.1989-2002
Hauptverfasser:	Li, Dan, Guo, Ying-ying, Cen, Xian-feng, Qiu, Hong-liang, Chen, Si, Zeng, Xiao-feng, Zeng, Qian, Xu, Man, Tang, Qi-zhu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acids Agonists AKT protein Animals Aorta Apoptosis Biomedical and Life Sciences Biomedicine Cardiomegaly - drug therapy Cardiomegaly - metabolism Cardiomegaly - prevention & control Cardiomyocytes Cardiovascular diseases Cytokines Cytotoxicity Fibrosis Genes Herbal medicine Hypertrophy Immunology Inflammation Internal Medicine Kinases Laboratory animals Medical Microbiology Mice Mice, Inbred C57BL Myocytes, Cardiac Neonates NF-kappa B - metabolism NF-κB protein Nuclear transport Oxidative stress Pentacyclic Triterpenes - pharmacology Pharmacology/Toxicology Phenylephrine Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Signal Transduction TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Vaccine
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