Smell and Taste Dysfunction in Pediatric Patients With SARS-CoV-2 Infection
Anosmia and hypogeusia are frequent symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults, but their incidence in children is unknown. Describe the incidence and associated characteristics of olfactory and gustatory dysfunction in children with SARS-CoV-2 infec...
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| Veröffentlicht in: | Pediatric neurology 2022-11, Vol.136, p.28-33 |
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| creator | Púa Torrejón, Ruth Camila Ordoño Saiz, María Victoria González Alguacil, Elena Furones García, Marta Cantarín Extremera, Verónica Ruiz Falcó, María Luz Soto Insuga, Víctor |
| description | Anosmia and hypogeusia are frequent symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults, but their incidence in children is unknown.
Describe the incidence and associated characteristics of olfactory and gustatory dysfunction in children with SARS-CoV-2 infection.
Descriptive study carried out by telephone survey of patients aged between five and 18 years with SARS-CoV-2 infection confirmed between March and December, 2020.
Two hundred eighty Spanish patients (female: 42.2%) with a mean age of 10.4 years (±3.54, range: 5 to 17) were analyzed, 22.5% with other diseases (mostly respiratory: 11.8%). The most frequent symptoms were fever (55.36%) and neurological symptoms (45.7%). Forty-four (15.7%) were hospitalized due to the infection, in intensive care unit (ICU): 7.1%. Forty-five patients (16.1%) had anosmia and/or hypogeusia: 32 both, eight with hypogeusia only, and five with exclusively anosmia. The mean symptom duration in days for anosmia was 36.4, and for hypogeusia it was 27.6. Either symptom was the initial manifestation in 15 patients. None had anosmia/hypogeusia with no other symptoms. Anosmia/hypogeusia was related to the presence of respiratory infection, gastroenteritis, chills, odynophagia, myalgia, asthenia, and anorexia, but not severity (hospitalization/ICU admission). Cohabitation with another infected individual was associated with a higher incidence of anosmia/hypogeusia (P = 0.041) and duration of anosmia (P = 0.006). The presence of anosmia/hypogeusia in cohabitants was associated with longer duration of anosmia (P |
| doi_str_mv | 10.1016/j.pediatrneurol.2022.07.006 |
| format | Article |
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Describe the incidence and associated characteristics of olfactory and gustatory dysfunction in children with SARS-CoV-2 infection.
Descriptive study carried out by telephone survey of patients aged between five and 18 years with SARS-CoV-2 infection confirmed between March and December, 2020.
Two hundred eighty Spanish patients (female: 42.2%) with a mean age of 10.4 years (±3.54, range: 5 to 17) were analyzed, 22.5% with other diseases (mostly respiratory: 11.8%). The most frequent symptoms were fever (55.36%) and neurological symptoms (45.7%). Forty-four (15.7%) were hospitalized due to the infection, in intensive care unit (ICU): 7.1%. Forty-five patients (16.1%) had anosmia and/or hypogeusia: 32 both, eight with hypogeusia only, and five with exclusively anosmia. The mean symptom duration in days for anosmia was 36.4, and for hypogeusia it was 27.6. Either symptom was the initial manifestation in 15 patients. None had anosmia/hypogeusia with no other symptoms. Anosmia/hypogeusia was related to the presence of respiratory infection, gastroenteritis, chills, odynophagia, myalgia, asthenia, and anorexia, but not severity (hospitalization/ICU admission). Cohabitation with another infected individual was associated with a higher incidence of anosmia/hypogeusia (P = 0.041) and duration of anosmia (P = 0.006). The presence of anosmia/hypogeusia in cohabitants was associated with longer duration of anosmia (P < 0.001).
The incidence of anosmia/hypogeusia in children with SARS-CoV-2 was lower than that reported in adults, although with a longer duration. Although no association was found between anosmia/hypogeusia and greater disease severity, recognition of these symptoms could help identify paucisymptomatic patients.</description><identifier>ISSN: 0887-8994</identifier><identifier>ISSN: 1873-5150</identifier><identifier>EISSN: 1873-5150</identifier><identifier>DOI: 10.1016/j.pediatrneurol.2022.07.006</identifier><identifier>PMID: 36084419</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Ageusia ; Ageusia - epidemiology ; Ageusia - etiology ; Anosmia ; Child ; Child, Preschool ; Children ; Coronavirus ; COVID-19 - complications ; Female ; Humans ; Olfaction Disorders - diagnosis ; Olfaction Disorders - epidemiology ; Olfaction Disorders - etiology ; Paucisymptomatic ; Research Paper ; SARS-CoV-2 ; Smell ; Taste Disorders - complications ; Taste Disorders - etiology</subject><ispartof>Pediatric neurology, 2022-11, Vol.136, p.28-33</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><rights>2022 Elsevier Inc. All rights reserved. 2022 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-4e66a961d0f40c208a3d5004efe2d5cb6f60767cd58c579f1c78b80735e64f293</citedby><cites>FETCH-LOGICAL-c421t-4e66a961d0f40c208a3d5004efe2d5cb6f60767cd58c579f1c78b80735e64f293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pediatrneurol.2022.07.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36084419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Púa Torrejón, Ruth Camila</creatorcontrib><creatorcontrib>Ordoño Saiz, María Victoria</creatorcontrib><creatorcontrib>González Alguacil, Elena</creatorcontrib><creatorcontrib>Furones García, Marta</creatorcontrib><creatorcontrib>Cantarín Extremera, Verónica</creatorcontrib><creatorcontrib>Ruiz Falcó, María Luz</creatorcontrib><creatorcontrib>Soto Insuga, Víctor</creatorcontrib><title>Smell and Taste Dysfunction in Pediatric Patients With SARS-CoV-2 Infection</title><title>Pediatric neurology</title><addtitle>Pediatr Neurol</addtitle><description>Anosmia and hypogeusia are frequent symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults, but their incidence in children is unknown.
Describe the incidence and associated characteristics of olfactory and gustatory dysfunction in children with SARS-CoV-2 infection.
Descriptive study carried out by telephone survey of patients aged between five and 18 years with SARS-CoV-2 infection confirmed between March and December, 2020.
Two hundred eighty Spanish patients (female: 42.2%) with a mean age of 10.4 years (±3.54, range: 5 to 17) were analyzed, 22.5% with other diseases (mostly respiratory: 11.8%). The most frequent symptoms were fever (55.36%) and neurological symptoms (45.7%). Forty-four (15.7%) were hospitalized due to the infection, in intensive care unit (ICU): 7.1%. Forty-five patients (16.1%) had anosmia and/or hypogeusia: 32 both, eight with hypogeusia only, and five with exclusively anosmia. The mean symptom duration in days for anosmia was 36.4, and for hypogeusia it was 27.6. Either symptom was the initial manifestation in 15 patients. None had anosmia/hypogeusia with no other symptoms. Anosmia/hypogeusia was related to the presence of respiratory infection, gastroenteritis, chills, odynophagia, myalgia, asthenia, and anorexia, but not severity (hospitalization/ICU admission). Cohabitation with another infected individual was associated with a higher incidence of anosmia/hypogeusia (P = 0.041) and duration of anosmia (P = 0.006). The presence of anosmia/hypogeusia in cohabitants was associated with longer duration of anosmia (P < 0.001).
The incidence of anosmia/hypogeusia in children with SARS-CoV-2 was lower than that reported in adults, although with a longer duration. Although no association was found between anosmia/hypogeusia and greater disease severity, recognition of these symptoms could help identify paucisymptomatic patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Ageusia</subject><subject>Ageusia - epidemiology</subject><subject>Ageusia - etiology</subject><subject>Anosmia</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Coronavirus</subject><subject>COVID-19 - complications</subject><subject>Female</subject><subject>Humans</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfaction Disorders - epidemiology</subject><subject>Olfaction Disorders - etiology</subject><subject>Paucisymptomatic</subject><subject>Research Paper</subject><subject>SARS-CoV-2</subject><subject>Smell</subject><subject>Taste Disorders - complications</subject><subject>Taste Disorders - etiology</subject><issn>0887-8994</issn><issn>1873-5150</issn><issn>1873-5150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVFLHDEUhYNUdGv7FyTQl77MeJPJJBkKBdlalQqVrq2PIZtJapbZZJvMCP57s10r-tan-3DPPefyHYQ-EKgJEH6yqje293pMwU4pDjUFSmsQNQDfQzMiRVO1pIU3aAZSikp2HTtEb3NeAUDbUXaADhsOkjHSzdC3xdoOA9ahxzc6jxZ_echuCmb0MWAf8PUuyht8rUdvw5jxrR_v8OL0x6Kax18VxZfB2b_6d2jf6SHb90_zCP38enYzv6iuvp9fzk-vKsMoGStmOdcdJz04BoaC1E3fAjDrLO1bs-SOg-DC9K00regcMUIuJYimtZw52jVH6PPOdzMt17Y35aukB7VJfq3Tg4raq9eb4O_U73ivuoY1IEgx-PhkkOKfyeZRrX02hYMONk5ZUUGoZALINuvTTmpSzDlZ9xxDQG3rUCv1qg61rUOBUKWOcn388tPn23_8i-BsJ7CF1723SWVTKJvimApU1Uf_X0GPAHaj9Q</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Púa Torrejón, Ruth Camila</creator><creator>Ordoño Saiz, María Victoria</creator><creator>González Alguacil, Elena</creator><creator>Furones García, Marta</creator><creator>Cantarín Extremera, Verónica</creator><creator>Ruiz Falcó, María Luz</creator><creator>Soto Insuga, Víctor</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221101</creationdate><title>Smell and Taste Dysfunction in Pediatric Patients With SARS-CoV-2 Infection</title><author>Púa Torrejón, Ruth Camila ; Ordoño Saiz, María Victoria ; González Alguacil, Elena ; Furones García, Marta ; Cantarín Extremera, Verónica ; Ruiz Falcó, María Luz ; Soto Insuga, Víctor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-4e66a961d0f40c208a3d5004efe2d5cb6f60767cd58c579f1c78b80735e64f293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Ageusia</topic><topic>Ageusia - epidemiology</topic><topic>Ageusia - etiology</topic><topic>Anosmia</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Coronavirus</topic><topic>COVID-19 - complications</topic><topic>Female</topic><topic>Humans</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfaction Disorders - epidemiology</topic><topic>Olfaction Disorders - etiology</topic><topic>Paucisymptomatic</topic><topic>Research Paper</topic><topic>SARS-CoV-2</topic><topic>Smell</topic><topic>Taste Disorders - complications</topic><topic>Taste Disorders - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Púa Torrejón, Ruth Camila</creatorcontrib><creatorcontrib>Ordoño Saiz, María Victoria</creatorcontrib><creatorcontrib>González Alguacil, Elena</creatorcontrib><creatorcontrib>Furones García, Marta</creatorcontrib><creatorcontrib>Cantarín Extremera, Verónica</creatorcontrib><creatorcontrib>Ruiz Falcó, María Luz</creatorcontrib><creatorcontrib>Soto Insuga, Víctor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Púa Torrejón, Ruth Camila</au><au>Ordoño Saiz, María Victoria</au><au>González Alguacil, Elena</au><au>Furones García, Marta</au><au>Cantarín Extremera, Verónica</au><au>Ruiz Falcó, María Luz</au><au>Soto Insuga, Víctor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smell and Taste Dysfunction in Pediatric Patients With SARS-CoV-2 Infection</atitle><jtitle>Pediatric neurology</jtitle><addtitle>Pediatr Neurol</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>136</volume><spage>28</spage><epage>33</epage><pages>28-33</pages><issn>0887-8994</issn><issn>1873-5150</issn><eissn>1873-5150</eissn><abstract>Anosmia and hypogeusia are frequent symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults, but their incidence in children is unknown.
Describe the incidence and associated characteristics of olfactory and gustatory dysfunction in children with SARS-CoV-2 infection.
Descriptive study carried out by telephone survey of patients aged between five and 18 years with SARS-CoV-2 infection confirmed between March and December, 2020.
Two hundred eighty Spanish patients (female: 42.2%) with a mean age of 10.4 years (±3.54, range: 5 to 17) were analyzed, 22.5% with other diseases (mostly respiratory: 11.8%). The most frequent symptoms were fever (55.36%) and neurological symptoms (45.7%). Forty-four (15.7%) were hospitalized due to the infection, in intensive care unit (ICU): 7.1%. Forty-five patients (16.1%) had anosmia and/or hypogeusia: 32 both, eight with hypogeusia only, and five with exclusively anosmia. The mean symptom duration in days for anosmia was 36.4, and for hypogeusia it was 27.6. Either symptom was the initial manifestation in 15 patients. None had anosmia/hypogeusia with no other symptoms. Anosmia/hypogeusia was related to the presence of respiratory infection, gastroenteritis, chills, odynophagia, myalgia, asthenia, and anorexia, but not severity (hospitalization/ICU admission). Cohabitation with another infected individual was associated with a higher incidence of anosmia/hypogeusia (P = 0.041) and duration of anosmia (P = 0.006). The presence of anosmia/hypogeusia in cohabitants was associated with longer duration of anosmia (P < 0.001).
The incidence of anosmia/hypogeusia in children with SARS-CoV-2 was lower than that reported in adults, although with a longer duration. Although no association was found between anosmia/hypogeusia and greater disease severity, recognition of these symptoms could help identify paucisymptomatic patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36084419</pmid><doi>10.1016/j.pediatrneurol.2022.07.006</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Ageusia Ageusia - epidemiology Ageusia - etiology Anosmia Child Child, Preschool Children Coronavirus COVID-19 - complications Female Humans Olfaction Disorders - diagnosis Olfaction Disorders - epidemiology Olfaction Disorders - etiology Paucisymptomatic Research Paper SARS-CoV-2 Smell Taste Disorders - complications Taste Disorders - etiology |
| title | Smell and Taste Dysfunction in Pediatric Patients With SARS-CoV-2 Infection |
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