Radiation with STAT3 Blockade Triggers Dendritic Cell-T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy

Patients with central nervous system (CNS) tumors are typically treated with radiotherapy, but this is not curative and results in the upregulation of phosphorylated STAT3 (p-STAT3), which drives invasion, angiogenesis, and immune suppression. Therefore, we investigated the combined effect of an inh...

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Veröffentlicht in:Clinical cancer research 2020-09, Vol.26 (18), p.4983-4994
Hauptverfasser: Ott, Martina, Kassab, Cynthia, Marisetty, Anantha, Hashimoto, Yuuri, Wei, Jun, Zamler, Daniel, Leu, Jia-Shiun, Tomaszowski, Karl-Heinz, Sabbagh, Aria, Fang, Dexing, Gupta, Pravesh, Priebe, Waldemar, Zielinski, Rafal J, Burks, Jared K, Long, James P, Kong, Ling-Yuan, Fuller, Gregory N, DeGroot, John, Sulman, Erik P, Heimberger, Amy B
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Sprache:eng
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