Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration

Tissue wounding induces cutaneous sensory axon regeneration via hydrogen peroxide (H O ) that is produced by the epithelial NADPH oxidase, Duox1. Sciatic nerve injury instead induces axon regeneration through neuronal uptake of the NADPH oxidase, Nox2, from macrophages. We therefore reasoned that th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-07, Vol.119 (30), p.e2115009119
Hauptverfasser:	Cadiz Diaz, Antonio, Schmidt, Natalie A, Yamazaki, Mamiko, Hsieh, Chia-Jung, Lisse, Thomas S, Rieger, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Axons - physiology Biological Sciences Collagenase 3 CYBB protein Degeneration Depletion Epidermal growth factor Epidermal growth factor receptors Growth factors Hydrogen peroxide Hydrogen Peroxide - metabolism Keratinocytes - physiology Macrophages Matrix metalloproteinase Matrix metalloproteinases Metalloproteinase Mutants NAD(P)H oxidase NADPH Oxidases - genetics NADPH Oxidases - physiology Nerve Regeneration - genetics Neurodegeneration Oxidase Oxidation Phenotypes Regeneration Sciatic nerve Sensory neurons Sensory Receptor Cells - physiology Wound Healing - genetics Wound Healing - physiology Wounding Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - physiology
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