Evaluation of infarct core and ischemic penumbra by absolute quantitative cerebral dynamic susceptibility contrast perfusion magnetic resonance imaging using self-calibrated echo planar imaging sequencing in patients with acute ischemic stroke
BackgroundIt has been hypothesized that an absolute quantitative dynamic susceptibility contrast (DSC) cerebral perfusion-weighted imaging (PWI) technique based on self-calibrated echo-planar imaging (EPI) could be a reliable measurement of quantitative cerebral blood flow (qCBF) and quantitative ce...
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| Veröffentlicht in: | Quantitative imaging in medicine and surgery 2022-08, Vol.12 (8), p.4286-4295 |
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| creator | Ma, Xiaoyue Wang, Yan Wang, Mengke Zhang, Menghuan Meng, Nan Zhang, Long Zhang, Jinlong Dou, Shewei Wang, Meiyun |
| description | BackgroundIt has been hypothesized that an absolute quantitative dynamic susceptibility contrast (DSC) cerebral perfusion-weighted imaging (PWI) technique based on self-calibrated echo-planar imaging (EPI) could be a reliable measurement of quantitative cerebral blood flow (qCBF) and quantitative cerebral blood volume (qCBV). This study aimed to investigate the clinical value of this technique in offering a unique insight into ischemic stroke (IS) pathophysiology and improving the sensitivity of IS diagnosis. MethodsA total of 14 patients with IS who underwent routine magnetic resonance imaging (MRI) and Self-CALibrated EPI Perfusion-Weighted Imaging (SCALE-PWI) scanning were prospectively recruited as a consecutive convenience sample. qCBF and qCBV maps were processed immediately online after the scan. Then, 2 radiologists independently drew the region of interest (ROI) of the infarct core, ischemic penumbra, and the contralateral normal tissues on each map for the statistical analyses. The paired-samples t-test, Wilcoxon signed-rank test, independent-samples t-test, and receiver operating characteristic (ROC) curve were performed. A value of P |
| doi_str_mv | 10.21037/qims-21-975 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9338368</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2697673895</sourcerecordid><originalsourceid>FETCH-LOGICAL-c318t-a84a41d04ea7d3f5c25f11e6dcd6a999eb379734a3f9ef3f4d78463d9073169a3</originalsourceid><addsrcrecordid>eNpVUsFu1DAQjRCIVqU3PsBHDoTGcRLHFyRUtYBUiQucrYk93jU4dtZ2Fu138wM4tF0JH-yn8Zs370lTVW9p86GlDeM3BzunuqW14P2L6rJtW1Z3rBlePuNWtBfVdUo_m3L4SDltXlcXrBdUNP1wWf25O4JbIdvgSTDEegNRZaJCRAJeE5vUHmeryIJ-nacIZDoRmFJwa0ZyWMFnm0v7EYnCiIXgiD552FrSmhQu2U7W2Xwqmj5HSLlIRbOmbeIMO4-5UCOm4MErJLbUrN-RQih3QmdqBc4W4YyaoNoHsjjwEM_MhIcVvdqg9WQpZtDnRH7bvCegNpvnECnH8AvfVK8MuITXT-9V9eP-7vvtl_rh2-evt58easXomGsYO-iobjoErpnpVdsbSnHQSg8ghMCJccFZB8wINMx0mo_dwLRoOKODAHZVfXzUXdZpRq1wy-_kEovzeJIBrPz_x9u93IWjFIyNbBiLwLsngRhKxpTlXKKgK_kxrEm2g-ADZ6PoC_X9I1XFkFJEcx5DG_lvVeS2KgXKsirsL5ceuwc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2697673895</pqid></control><display><type>article</type><title>Evaluation of infarct core and ischemic penumbra by absolute quantitative cerebral dynamic susceptibility contrast perfusion magnetic resonance imaging using self-calibrated echo planar imaging sequencing in patients with acute ischemic stroke</title><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Ma, Xiaoyue ; Wang, Yan ; Wang, Mengke ; Zhang, Menghuan ; Meng, Nan ; Zhang, Long ; Zhang, Jinlong ; Dou, Shewei ; Wang, Meiyun</creator><creatorcontrib>Ma, Xiaoyue ; Wang, Yan ; Wang, Mengke ; Zhang, Menghuan ; Meng, Nan ; Zhang, Long ; Zhang, Jinlong ; Dou, Shewei ; Wang, Meiyun</creatorcontrib><description>BackgroundIt has been hypothesized that an absolute quantitative dynamic susceptibility contrast (DSC) cerebral perfusion-weighted imaging (PWI) technique based on self-calibrated echo-planar imaging (EPI) could be a reliable measurement of quantitative cerebral blood flow (qCBF) and quantitative cerebral blood volume (qCBV). This study aimed to investigate the clinical value of this technique in offering a unique insight into ischemic stroke (IS) pathophysiology and improving the sensitivity of IS diagnosis. MethodsA total of 14 patients with IS who underwent routine magnetic resonance imaging (MRI) and Self-CALibrated EPI Perfusion-Weighted Imaging (SCALE-PWI) scanning were prospectively recruited as a consecutive convenience sample. qCBF and qCBV maps were processed immediately online after the scan. Then, 2 radiologists independently drew the region of interest (ROI) of the infarct core, ischemic penumbra, and the contralateral normal tissues on each map for the statistical analyses. The paired-samples t-test, Wilcoxon signed-rank test, independent-samples t-test, and receiver operating characteristic (ROC) curve were performed. A value of P<0.05 was considered statistically significant with 95% confidence intervals (CI). ResultsAll the values of qCBF and qCBV in the lesions were lower than those in the contralateral normal tissues (all P<0.05). The values of qCBF and qCBV in the infarct core were lower than those in the ischemic penumbra (mean values: 16.42 vs. 21.54 mL/100 g/min, P=0.013; 1.23 vs. 1.47 mL/100 g, P=0.049, respectively). The qCBF threshold of the infarct core was 18.18 mL/100 g/min (sensitivity, 71.40%; specificity, 64.30%) and the qCBF threshold of the ischemic penumbra was 28.09 mL/100 g/min (sensitivity, 78.60%; specificity, 85.70%). ConclusionsDifferent from the previous semi-quantitative measurement, the SCALE-PWI technique has the potential to provide absolute quantitative hemodynamic information which may be used to detect the infarct core and ischemic penumbra in a relatively short scan time.</description><identifier>ISSN: 2223-4292</identifier><identifier>EISSN: 2223-4306</identifier><identifier>DOI: 10.21037/qims-21-975</identifier><identifier>PMID: 35919056</identifier><language>eng</language><publisher>AME Publishing Company</publisher><subject>Original</subject><ispartof>Quantitative imaging in medicine and surgery, 2022-08, Vol.12 (8), p.4286-4295</ispartof><rights>2022 Quantitative Imaging in Medicine and Surgery. All rights reserved. 2022 Quantitative Imaging in Medicine and Surgery.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338368/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338368/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids></links><search><creatorcontrib>Ma, Xiaoyue</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Wang, Mengke</creatorcontrib><creatorcontrib>Zhang, Menghuan</creatorcontrib><creatorcontrib>Meng, Nan</creatorcontrib><creatorcontrib>Zhang, Long</creatorcontrib><creatorcontrib>Zhang, Jinlong</creatorcontrib><creatorcontrib>Dou, Shewei</creatorcontrib><creatorcontrib>Wang, Meiyun</creatorcontrib><title>Evaluation of infarct core and ischemic penumbra by absolute quantitative cerebral dynamic susceptibility contrast perfusion magnetic resonance imaging using self-calibrated echo planar imaging sequencing in patients with acute ischemic stroke</title><title>Quantitative imaging in medicine and surgery</title><description>BackgroundIt has been hypothesized that an absolute quantitative dynamic susceptibility contrast (DSC) cerebral perfusion-weighted imaging (PWI) technique based on self-calibrated echo-planar imaging (EPI) could be a reliable measurement of quantitative cerebral blood flow (qCBF) and quantitative cerebral blood volume (qCBV). This study aimed to investigate the clinical value of this technique in offering a unique insight into ischemic stroke (IS) pathophysiology and improving the sensitivity of IS diagnosis. MethodsA total of 14 patients with IS who underwent routine magnetic resonance imaging (MRI) and Self-CALibrated EPI Perfusion-Weighted Imaging (SCALE-PWI) scanning were prospectively recruited as a consecutive convenience sample. qCBF and qCBV maps were processed immediately online after the scan. Then, 2 radiologists independently drew the region of interest (ROI) of the infarct core, ischemic penumbra, and the contralateral normal tissues on each map for the statistical analyses. The paired-samples t-test, Wilcoxon signed-rank test, independent-samples t-test, and receiver operating characteristic (ROC) curve were performed. A value of P<0.05 was considered statistically significant with 95% confidence intervals (CI). ResultsAll the values of qCBF and qCBV in the lesions were lower than those in the contralateral normal tissues (all P<0.05). The values of qCBF and qCBV in the infarct core were lower than those in the ischemic penumbra (mean values: 16.42 vs. 21.54 mL/100 g/min, P=0.013; 1.23 vs. 1.47 mL/100 g, P=0.049, respectively). The qCBF threshold of the infarct core was 18.18 mL/100 g/min (sensitivity, 71.40%; specificity, 64.30%) and the qCBF threshold of the ischemic penumbra was 28.09 mL/100 g/min (sensitivity, 78.60%; specificity, 85.70%). ConclusionsDifferent from the previous semi-quantitative measurement, the SCALE-PWI technique has the potential to provide absolute quantitative hemodynamic information which may be used to detect the infarct core and ischemic penumbra in a relatively short scan time.</description><subject>Original</subject><issn>2223-4292</issn><issn>2223-4306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVUsFu1DAQjRCIVqU3PsBHDoTGcRLHFyRUtYBUiQucrYk93jU4dtZ2Fu138wM4tF0JH-yn8Zs370lTVW9p86GlDeM3BzunuqW14P2L6rJtW1Z3rBlePuNWtBfVdUo_m3L4SDltXlcXrBdUNP1wWf25O4JbIdvgSTDEegNRZaJCRAJeE5vUHmeryIJ-nacIZDoRmFJwa0ZyWMFnm0v7EYnCiIXgiD552FrSmhQu2U7W2Xwqmj5HSLlIRbOmbeIMO4-5UCOm4MErJLbUrN-RQih3QmdqBc4W4YyaoNoHsjjwEM_MhIcVvdqg9WQpZtDnRH7bvCegNpvnECnH8AvfVK8MuITXT-9V9eP-7vvtl_rh2-evt58easXomGsYO-iobjoErpnpVdsbSnHQSg8ghMCJccFZB8wINMx0mo_dwLRoOKODAHZVfXzUXdZpRq1wy-_kEovzeJIBrPz_x9u93IWjFIyNbBiLwLsngRhKxpTlXKKgK_kxrEm2g-ADZ6PoC_X9I1XFkFJEcx5DG_lvVeS2KgXKsirsL5ceuwc</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Ma, Xiaoyue</creator><creator>Wang, Yan</creator><creator>Wang, Mengke</creator><creator>Zhang, Menghuan</creator><creator>Meng, Nan</creator><creator>Zhang, Long</creator><creator>Zhang, Jinlong</creator><creator>Dou, Shewei</creator><creator>Wang, Meiyun</creator><general>AME Publishing Company</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202208</creationdate><title>Evaluation of infarct core and ischemic penumbra by absolute quantitative cerebral dynamic susceptibility contrast perfusion magnetic resonance imaging using self-calibrated echo planar imaging sequencing in patients with acute ischemic stroke</title><author>Ma, Xiaoyue ; Wang, Yan ; Wang, Mengke ; Zhang, Menghuan ; Meng, Nan ; Zhang, Long ; Zhang, Jinlong ; Dou, Shewei ; Wang, Meiyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-a84a41d04ea7d3f5c25f11e6dcd6a999eb379734a3f9ef3f4d78463d9073169a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Ma, Xiaoyue</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Wang, Mengke</creatorcontrib><creatorcontrib>Zhang, Menghuan</creatorcontrib><creatorcontrib>Meng, Nan</creatorcontrib><creatorcontrib>Zhang, Long</creatorcontrib><creatorcontrib>Zhang, Jinlong</creatorcontrib><creatorcontrib>Dou, Shewei</creatorcontrib><creatorcontrib>Wang, Meiyun</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Quantitative imaging in medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Xiaoyue</au><au>Wang, Yan</au><au>Wang, Mengke</au><au>Zhang, Menghuan</au><au>Meng, Nan</au><au>Zhang, Long</au><au>Zhang, Jinlong</au><au>Dou, Shewei</au><au>Wang, Meiyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of infarct core and ischemic penumbra by absolute quantitative cerebral dynamic susceptibility contrast perfusion magnetic resonance imaging using self-calibrated echo planar imaging sequencing in patients with acute ischemic stroke</atitle><jtitle>Quantitative imaging in medicine and surgery</jtitle><date>2022-08</date><risdate>2022</risdate><volume>12</volume><issue>8</issue><spage>4286</spage><epage>4295</epage><pages>4286-4295</pages><issn>2223-4292</issn><eissn>2223-4306</eissn><abstract>BackgroundIt has been hypothesized that an absolute quantitative dynamic susceptibility contrast (DSC) cerebral perfusion-weighted imaging (PWI) technique based on self-calibrated echo-planar imaging (EPI) could be a reliable measurement of quantitative cerebral blood flow (qCBF) and quantitative cerebral blood volume (qCBV). This study aimed to investigate the clinical value of this technique in offering a unique insight into ischemic stroke (IS) pathophysiology and improving the sensitivity of IS diagnosis. MethodsA total of 14 patients with IS who underwent routine magnetic resonance imaging (MRI) and Self-CALibrated EPI Perfusion-Weighted Imaging (SCALE-PWI) scanning were prospectively recruited as a consecutive convenience sample. qCBF and qCBV maps were processed immediately online after the scan. Then, 2 radiologists independently drew the region of interest (ROI) of the infarct core, ischemic penumbra, and the contralateral normal tissues on each map for the statistical analyses. The paired-samples t-test, Wilcoxon signed-rank test, independent-samples t-test, and receiver operating characteristic (ROC) curve were performed. A value of P<0.05 was considered statistically significant with 95% confidence intervals (CI). ResultsAll the values of qCBF and qCBV in the lesions were lower than those in the contralateral normal tissues (all P<0.05). The values of qCBF and qCBV in the infarct core were lower than those in the ischemic penumbra (mean values: 16.42 vs. 21.54 mL/100 g/min, P=0.013; 1.23 vs. 1.47 mL/100 g, P=0.049, respectively). The qCBF threshold of the infarct core was 18.18 mL/100 g/min (sensitivity, 71.40%; specificity, 64.30%) and the qCBF threshold of the ischemic penumbra was 28.09 mL/100 g/min (sensitivity, 78.60%; specificity, 85.70%). ConclusionsDifferent from the previous semi-quantitative measurement, the SCALE-PWI technique has the potential to provide absolute quantitative hemodynamic information which may be used to detect the infarct core and ischemic penumbra in a relatively short scan time.</abstract><pub>AME Publishing Company</pub><pmid>35919056</pmid><doi>10.21037/qims-21-975</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| title | Evaluation of infarct core and ischemic penumbra by absolute quantitative cerebral dynamic susceptibility contrast perfusion magnetic resonance imaging using self-calibrated echo planar imaging sequencing in patients with acute ischemic stroke |
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