$nextMONARCH Phase 2 randomized clinical trial: overall survival analysis of abemaciclib monotherapy or in combination with tamoxifen in patients with endocrine-refractory HR + , HER2– metastatic breast cancer$

nextMONARCH Phase 2 randomized clinical trial: overall survival analysis of abemaciclib monotherapy or in combination with tamoxifen in patients with endocrine-refractory HR + , HER2– metastatic breast cancer

Purpose Resistance to endocrine therapy poses a major clinical challenge for patients with hormone receptor-positive (HR +), human epidermal growth factor receptor 2-negative (HER2–) metastatic breast cancer (MBC). We present the preplanned 24-month final overall survival (OS) results, alongside upd...

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Veröffentlicht in:	Breast cancer research and treatment 2022-08, Vol.195 (1), p.55-64
Hauptverfasser:	Hamilton, Erika, Cortes, Javier, Ozyilkan, Ozgur, Chen, Shin-Cheh, Petrakova, Katarina, Manikhas, Aleksey, Jerusalem, Guy, Hegg, Roberto, Huober, Jens, Zhang, Wei, Chen, Yanyun, Martin, Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	abemaciclib Aminopyridines Aminopyridines/adverse effects Antimitotic agents Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols/adverse effects Benzimidazoles Benzimidazoles/adverse effects Breast cancer Breast Neoplasms Breast Neoplasms/drug therapy Breast Neoplasms/pathology Cancer Cancer Research Chemotherapy Clinical Trial Clinical trials Cyclin-dependent kinase 4 and 6 Endocrine therapy Epidermal growth factor ErbB-2 protein Female HER2-negative Hormone receptor-positive Human health sciences Humans Loperamide MBC Medical research Medicine Medicine & Public Health Medicine, Experimental Metastases Metastasis NCT NCT02747004 Oncologie Oncology Overall survival Patient outcomes Patients Product development Progression-Free Survival Receptor, ErbB-2 Safety Sciences de la santé humaine Survival Survival analysis Tamoxifen Tamoxifen/therapeutic use
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