A multiplexed in vitro assay system for evaluating human skeletal muscle functionality in response to drug treatment

In vitro systems that mimic organ functionality have become increasingly important tools in drug development studies. Systems that measure the functional properties of skeletal muscle are beneficial to compound screening studies and also for integration into multiorgan devices. To date, no studies h...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-03, Vol.117 (3), p.736-747
Hauptverfasser:	Najjar, Sarah A., Smith, Alexander S.T., Long, Christopher J., McAleer, Christopher W., Cai, Yunqing, Srinivasan, Balaji, Martin, Candace, Vandenburgh, Herman H., Hickman, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atorvastatin - toxicity body‐on‐a‐chip cantilevers Cells, Cultured Data collection Doxorubicin - toxicity Drug development Drug Evaluation, Preclinical - methods Electrical stimuli functional assay human Human performance Humans Induced Pluripotent Stem Cells - drug effects Lab-On-A-Chip Devices Models, Biological Muscle contraction Muscle Contraction - drug effects Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - drug effects Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Muscles Muscular Dystrophies - metabolism Muscular fatigue Musculoskeletal system Myotubes Physiological responses Screening Skeletal muscle
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