Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein–Protein Interactions

Protein–protein interactions (PPIs) form complex networks to drive cellular signaling and cellular functions. Precise modulation of a target PPI helps explain the role of the PPI in cellular events and possesses therapeutic potential. For example, valosin-containing protein (VCP/p97) is a hub protei...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2022-07, Vol.144 (29), p.13218-13225
Hauptverfasser:	Jiang, Ziwen, Kuo, Yu-Hsuan, Zhong, Mengqi, Zhang, Jianchao, Zhou, Xin X., Xing, Lijuan, Wells, James A., Wang, Yanzhuang, Arkin, Michelle R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adenosine Triphosphatases - metabolism Cell Cycle Proteins - chemistry Immunoglobulin Fragments Protein Binding Valosin Containing Protein - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!