Anti-MDA5 Antibody-positive Dermatomyositis with Rapidly Progressive Interstitial Pneumonia Presenting with Nephrotic Syndrome during Treatment with Corticosteroids and Cyclosporine
A 50-year-old Japanese woman with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis presenting with rapidly progressive interstitial pneumonia was treated with corticosteroids and cyclosporine. She developed nephrotic syndrome during the treatment...
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| Veröffentlicht in: | Internal Medicine 2022/07/01, Vol.61(13), pp.2007-2012 |
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| container_end_page | 2012 |
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| container_issue | 13 |
| container_start_page | 2007 |
| container_title | Internal Medicine |
| container_volume | 61 |
| creator | Kawamoto, Shinya Abe, Toshihiro Nagahori, Katsuhiro Yoshino, Atsunori Fujii, Akiko Ono, Yuko Ueda, Yoshihiko Takeda, Tetsuro |
| description | A 50-year-old Japanese woman with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis presenting with rapidly progressive interstitial pneumonia was treated with corticosteroids and cyclosporine. She developed nephrotic syndrome during the treatment regimen with corticosteroids and cyclosporine. A kidney biopsy revealed a thrombotic microangiopathy (TMA) glomerular lesion. Anti-MDA5 antibody-positive dermatomyositis is prone to severe interstitial lung disease (ILD) and is often exacerbated and refractory to treatment. Renal symptoms might be due to TMA of the kidney, and this may be a sign that more intensive treatment is needed. Patients sometimes develop acute kidney injury, which may be due to the TMA. |
| doi_str_mv | 10.2169/internalmedicine.8311-21 |
| format | Article |
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She developed nephrotic syndrome during the treatment regimen with corticosteroids and cyclosporine. A kidney biopsy revealed a thrombotic microangiopathy (TMA) glomerular lesion. Anti-MDA5 antibody-positive dermatomyositis is prone to severe interstitial lung disease (ILD) and is often exacerbated and refractory to treatment. Renal symptoms might be due to TMA of the kidney, and this may be a sign that more intensive treatment is needed. Patients sometimes develop acute kidney injury, which may be due to the TMA.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.8311-21</identifier><identifier>PMID: 34776485</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>anti-MDA5 antibody-positive dermatomyositis ; Biopsy ; Case Report ; Corticosteroids ; cyclosporine ; Cyclosporins ; Dermatomyositis ; Internal medicine ; Kidneys ; Lung diseases ; Medical treatment ; Melanoma ; Nephrotic syndrome ; Pneumonia ; rapidly progressive interstitial pneumonia ; Thrombotic microangiopathy</subject><ispartof>Internal Medicine, 2022/07/01, Vol.61(13), pp.2007-2012</ispartof><rights>2022 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><rights>Copyright © 2022 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-e12bcebf8e855caa80771a693850d632c746cc0e5b6c1db22fa0857cd0f4784c3</citedby><cites>FETCH-LOGICAL-c587t-e12bcebf8e855caa80771a693850d632c746cc0e5b6c1db22fa0857cd0f4784c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334254/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334254/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1876,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Kawamoto, Shinya</creatorcontrib><creatorcontrib>Abe, Toshihiro</creatorcontrib><creatorcontrib>Nagahori, Katsuhiro</creatorcontrib><creatorcontrib>Yoshino, Atsunori</creatorcontrib><creatorcontrib>Fujii, Akiko</creatorcontrib><creatorcontrib>Ono, Yuko</creatorcontrib><creatorcontrib>Ueda, Yoshihiko</creatorcontrib><creatorcontrib>Takeda, Tetsuro</creatorcontrib><title>Anti-MDA5 Antibody-positive Dermatomyositis with Rapidly Progressive Interstitial Pneumonia Presenting with Nephrotic Syndrome during Treatment with Corticosteroids and Cyclosporine</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 50-year-old Japanese woman with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis presenting with rapidly progressive interstitial pneumonia was treated with corticosteroids and cyclosporine. She developed nephrotic syndrome during the treatment regimen with corticosteroids and cyclosporine. A kidney biopsy revealed a thrombotic microangiopathy (TMA) glomerular lesion. Anti-MDA5 antibody-positive dermatomyositis is prone to severe interstitial lung disease (ILD) and is often exacerbated and refractory to treatment. Renal symptoms might be due to TMA of the kidney, and this may be a sign that more intensive treatment is needed. Patients sometimes develop acute kidney injury, which may be due to the TMA.</description><subject>anti-MDA5 antibody-positive dermatomyositis</subject><subject>Biopsy</subject><subject>Case Report</subject><subject>Corticosteroids</subject><subject>cyclosporine</subject><subject>Cyclosporins</subject><subject>Dermatomyositis</subject><subject>Internal medicine</subject><subject>Kidneys</subject><subject>Lung diseases</subject><subject>Medical treatment</subject><subject>Melanoma</subject><subject>Nephrotic syndrome</subject><subject>Pneumonia</subject><subject>rapidly progressive interstitial pneumonia</subject><subject>Thrombotic microangiopathy</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNplkt1u1DAQhSMEoqXwDpa44SbFP3Hs3CCttgUqFVpBubYcZ3bXq8QOtlOUB-P9cNjVSpSbseX5ztHReIoCEXxJSd28ty5BcLofoLPGOriUjJCSkmfFOWFVUwrK-PPiHDdEljSXs-JVjHuMmRQNfVmcsUqIupL8vPi9csmWX65WHC231ndzOfpok30EdAVh0MkP89-HiH7ZtEPf9Gi7fkb3wW8DxLiAN0uemDKke3TvYBq8szojECG7uu1B-hXGXfDJGvR9dl3wA6BuCkv7IYBOQ2YP4NqHTPmYXb3tItKuQ-vZ9D6OPvPwunix0X2EN8fzovjx8fph_bm8vft0s17dloZLkUogtDXQbiRIzo3WEgtBdN0wyXFXM2pEVRuDgbe1IV1L6UZjyYXp8KYSsjLsovhw8B2nNs_a5IBB92oMdtBhVl5b9W_H2Z3a-kfVMFZRXmWDd0eD4H9OEJMabDTQ99qBn6KivBGS4kaSjL59gu79tHxypmrJaMVrwjIlD5QJPsYAm1MYgtWyG-rpbqhlN3IrS-8O0n1MegsnoV5m3cP_wpoowpZ6dDiRZqeDAsf-ACx51Wc</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Kawamoto, Shinya</creator><creator>Abe, Toshihiro</creator><creator>Nagahori, Katsuhiro</creator><creator>Yoshino, Atsunori</creator><creator>Fujii, Akiko</creator><creator>Ono, Yuko</creator><creator>Ueda, Yoshihiko</creator><creator>Takeda, Tetsuro</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220701</creationdate><title>Anti-MDA5 Antibody-positive Dermatomyositis with Rapidly Progressive Interstitial Pneumonia Presenting with Nephrotic Syndrome during Treatment with Corticosteroids and Cyclosporine</title><author>Kawamoto, Shinya ; Abe, Toshihiro ; Nagahori, Katsuhiro ; Yoshino, Atsunori ; Fujii, Akiko ; Ono, Yuko ; Ueda, Yoshihiko ; Takeda, Tetsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-e12bcebf8e855caa80771a693850d632c746cc0e5b6c1db22fa0857cd0f4784c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>anti-MDA5 antibody-positive dermatomyositis</topic><topic>Biopsy</topic><topic>Case Report</topic><topic>Corticosteroids</topic><topic>cyclosporine</topic><topic>Cyclosporins</topic><topic>Dermatomyositis</topic><topic>Internal medicine</topic><topic>Kidneys</topic><topic>Lung diseases</topic><topic>Medical treatment</topic><topic>Melanoma</topic><topic>Nephrotic syndrome</topic><topic>Pneumonia</topic><topic>rapidly progressive interstitial pneumonia</topic><topic>Thrombotic microangiopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawamoto, Shinya</creatorcontrib><creatorcontrib>Abe, Toshihiro</creatorcontrib><creatorcontrib>Nagahori, Katsuhiro</creatorcontrib><creatorcontrib>Yoshino, Atsunori</creatorcontrib><creatorcontrib>Fujii, Akiko</creatorcontrib><creatorcontrib>Ono, Yuko</creatorcontrib><creatorcontrib>Ueda, Yoshihiko</creatorcontrib><creatorcontrib>Takeda, Tetsuro</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawamoto, Shinya</au><au>Abe, Toshihiro</au><au>Nagahori, Katsuhiro</au><au>Yoshino, Atsunori</au><au>Fujii, Akiko</au><au>Ono, Yuko</au><au>Ueda, Yoshihiko</au><au>Takeda, Tetsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-MDA5 Antibody-positive Dermatomyositis with Rapidly Progressive Interstitial Pneumonia Presenting with Nephrotic Syndrome during Treatment with Corticosteroids and Cyclosporine</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>61</volume><issue>13</issue><spage>2007</spage><epage>2012</epage><pages>2007-2012</pages><artnum>8311-21</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 50-year-old Japanese woman with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis presenting with rapidly progressive interstitial pneumonia was treated with corticosteroids and cyclosporine. She developed nephrotic syndrome during the treatment regimen with corticosteroids and cyclosporine. A kidney biopsy revealed a thrombotic microangiopathy (TMA) glomerular lesion. Anti-MDA5 antibody-positive dermatomyositis is prone to severe interstitial lung disease (ILD) and is often exacerbated and refractory to treatment. Renal symptoms might be due to TMA of the kidney, and this may be a sign that more intensive treatment is needed. Patients sometimes develop acute kidney injury, which may be due to the TMA.</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>34776485</pmid><doi>10.2169/internalmedicine.8311-21</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central |
| subjects | anti-MDA5 antibody-positive dermatomyositis Biopsy Case Report Corticosteroids cyclosporine Cyclosporins Dermatomyositis Internal medicine Kidneys Lung diseases Medical treatment Melanoma Nephrotic syndrome Pneumonia rapidly progressive interstitial pneumonia Thrombotic microangiopathy |
| title | Anti-MDA5 Antibody-positive Dermatomyositis with Rapidly Progressive Interstitial Pneumonia Presenting with Nephrotic Syndrome during Treatment with Corticosteroids and Cyclosporine |
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