Importance of Locations of Iron Ions to Elicit Cytotoxicity Induced by a Fenton-Type Reaction

The impact of the site of the Fenton reaction, i.e., hydroxyl radical (•OH) generation, on cytotoxicity was investigated by estimating cell lethality in rat thymocytes. Cells were incubated with ferrous sulfate (FeSO4) and hydrogen peroxide (H2O2), or pre-incubated with FeSO4 and then H2O2 was added...

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Veröffentlicht in:	Cancers 2022-07, Vol.14 (15), p.3642
Hauptverfasser:	Igarashi, Kintaro, Shoji, Yoshimi, Sekine-Suzuki, Emiko, Ueno, Megumi, Matsumoto, Ken-ichiro, Nakanishi, Ikuo, Fukui, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell death Cytotoxicity Deoxyribonucleic acid DNA DNA damage Experiments Ferrous sulfate Flow cytometry Hydrogen peroxide Hydroxyl radicals Ions Iron Lethality Oxidative stress Radiation Reactive oxygen species Thymocytes Thymus gland
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