Magnetic resonance spectroscopic evidence of increased choline in the dorsolateral prefrontal and visual cortices in recent onset schizophrenia

•Dorsolateral prefrontal cortex dysfunction is evident in recent onset schizophrenia.•Elevated choline-containing metabolites were observed in DLPFC in such patients.•Similar elevation of the 1H-MRS choline signal was observed in the visual cortex.•Increased choline may reflect membrane remodeling a...

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Veröffentlicht in:	Neuroscience letters 2022-01, Vol.770, p.136410-136410, Article 136410
Hauptverfasser:	Smucny, Jason, Carter, Cameron S., Maddock, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aspartic Acid - metabolism Choline - metabolism Cortex Creatine - metabolism Female Glutamate Glutamic Acid - metabolism Humans Magnetic Resonance Imaging Male MRS NAA Occipital Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - metabolism Psychosis Schizophrenia - diagnostic imaging Schizophrenia - metabolism Visual Cortex - diagnostic imaging Visual Cortex - metabolism
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