Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer's Disease and Other Neurodegenerative Diseases

Alzheimer's disease (AD) is considered the most prevalent neurodegenerative disease and the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1-phosphate, are bioactive molecules implicated in structural and signaling functions. Metabolic dysfunction in the hig...

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Veröffentlicht in:	International journal of molecular sciences 2022-07, Vol.23 (15), p.8082
Hauptverfasser:	Custodia, Antía, Romaus-Sanjurjo, Daniel, Aramburu-Núñez, Marta, Álvarez-Rafael, Diego, Vázquez-Vázquez, Laura, Camino-Castiñeiras, Javier, Leira, Yago, Pías-Peleteiro, Juan Manuel, Aldrey, José Manuel, Sobrino, Tomás, Ouro, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - diagnosis Alzheimer Disease - metabolism Alzheimer Disease - therapy Alzheimer's disease Biomarkers Ceramide Ceramides - metabolism Dementia disorders Humans Kinases Lipid metabolism Lipids Lysophospholipids Metabolites Neurodegeneration Neurodegenerative Diseases - diagnosis Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - therapy Review Sphingolipids Sphingolipids - metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine 1-phosphate Transcriptomics
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