Impact of Statin Use on Localized Prostate Cancer Outcomes after Radiation Therapy: Long-Term Follow-Up

The impact of statin use on localized prostate cancer (PCa) remains controversial, especially for patients treated with radiation therapy. We assessed the impact of statin use on biochemical recurrence (BCR) in patients treated for PCa with different modalities of radiation therapy. We evaluated 355...

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Veröffentlicht in:Cancers 2022-07, Vol.14 (15), p.3606
Hauptverfasser: Kaulanjan, Kevin, Lavigne, Danny, Saad, Fred, Karakiewicz, Pierre I., Flammia, Rocco Simone, Kluth, Luis Alex, Mandel, Philipp, Chun, Felix K. -H., Taussky, Daniel, Hoeh, Benedikt
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container_end_page
container_issue 15
container_start_page 3606
container_title Cancers
container_volume 14
creator Kaulanjan, Kevin
Lavigne, Danny
Saad, Fred
Karakiewicz, Pierre I.
Flammia, Rocco Simone
Kluth, Luis Alex
Mandel, Philipp
Chun, Felix K. -H.
Taussky, Daniel
Hoeh, Benedikt
description The impact of statin use on localized prostate cancer (PCa) remains controversial, especially for patients treated with radiation therapy. We assessed the impact of statin use on biochemical recurrence (BCR) in patients treated for PCa with different modalities of radiation therapy. We evaluated 3555 patients undergoing radiation therapy between January 2001 and January 2022. The impact of statin use on BCR was analyzed for three treatment groups: external beam radiotherapy (EBRT), low-dose-rate seed brachytherapy (LDR), and EBRT plus high-dose-rate brachytherapy (EBRT + HDR). Median follow-up was 52 months among 1208 patients treated with EBRT, 1679 patients treated with LDR, and 599 patients treated with EBRT + HDR. A total of 1544 (43%) patients were taking a statin at the time of treatment, and 497 (14%) patients were in the D’Amico high-risk group. Only intermediate-risk patients treated with LDR fared better with statin use in univariate analysis (p = 0.025). This association was not significant in multivariate analysis (HR 0.44, 95% CI 0.18–1.10, p = 0.06). Statin use was not associated with a reduced risk of BCR in patients treated with radiation therapy. In the era of precision medicine, further investigation is needed to assess the benefit of statins in well-defined patients.
doi_str_mv 10.3390/cancers14153606
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We assessed the impact of statin use on biochemical recurrence (BCR) in patients treated for PCa with different modalities of radiation therapy. We evaluated 3555 patients undergoing radiation therapy between January 2001 and January 2022. The impact of statin use on BCR was analyzed for three treatment groups: external beam radiotherapy (EBRT), low-dose-rate seed brachytherapy (LDR), and EBRT plus high-dose-rate brachytherapy (EBRT + HDR). Median follow-up was 52 months among 1208 patients treated with EBRT, 1679 patients treated with LDR, and 599 patients treated with EBRT + HDR. A total of 1544 (43%) patients were taking a statin at the time of treatment, and 497 (14%) patients were in the D’Amico high-risk group. Only intermediate-risk patients treated with LDR fared better with statin use in univariate analysis (p = 0.025). This association was not significant in multivariate analysis (HR 0.44, 95% CI 0.18–1.10, p = 0.06). Statin use was not associated with a reduced risk of BCR in patients treated with radiation therapy. In the era of precision medicine, further investigation is needed to assess the benefit of statins in well-defined patients.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14153606</identifier><identifier>PMID: 35892865</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Androgens ; Antitumor agents ; Brachytherapy ; Cancer therapies ; Classification ; Multivariate analysis ; Patients ; Population ; Precision medicine ; Prostate cancer ; Radiation therapy ; Risk groups ; Statins</subject><ispartof>Cancers, 2022-07, Vol.14 (15), p.3606</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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subjects Androgens
Antitumor agents
Brachytherapy
Cancer therapies
Classification
Multivariate analysis
Patients
Population
Precision medicine
Prostate cancer
Radiation therapy
Risk groups
Statins
title Impact of Statin Use on Localized Prostate Cancer Outcomes after Radiation Therapy: Long-Term Follow-Up
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