1,4-Naphthoquinone (CNN1) Induces Apoptosis through DNA Damage and Promotes Upregulation of H2AFX in Leukemia Multidrug Resistant Cell Line

The multidrug resistance (MDR) phenotype is one of the major obstacles in the treatment of chronic myeloid leukemia (CML) in advantage stages such as blast crisis. In this scenario, more patients develop resistance mechanisms during the course of the disease, making tyrosine kinase inhibitors (TKIs)...

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Veröffentlicht in:	International journal of molecular sciences 2022-07, Vol.23 (15), p.8105
Hauptverfasser:	de Sousa Portilho, Adrhyann Jullyanne, da Silva, Emerson Lucena, Bezerra, Emanuel Cintra Austregésilo, Moraes Rego Gomes, Carinne Borges de Souza, Ferreira, Vitor, de Moraes, Maria Elisabete Amaral, da Rocha, David Rodrigues, Burbano, Rommel Mário Rodriguez, Moreira-Nunes, Caroline Aquino, Montenegro, Raquel Carvalho
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Blast crisis Cell cycle Cell Line, Tumor Cell membranes Chronic myeloid leukemia Comet assay Cytotoxicity Deoxyribonucleic acid Depolarization DNA DNA Damage DNA fragmentation Drug resistance Drug Resistance, Neoplasm - genetics Evaluation Flow cytometry Gene expression Genotoxicity Humans Imatinib Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myeloid - drug therapy Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Membrane potential Mitochondria Multidrug resistance Multidrug resistant organisms Myeloid leukemia Naphthoquinones - pharmacology Peripheral blood mononuclear cells Phenotypes Propidium iodide Tumor cell lines Tyrosine Up-Regulation
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