HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance

Background: Breast cancer has one of highest morbidity and mortality rates for women. Abnormalities regarding epigenetics modification and pyruvate dehydrogenase kinase 1 (PDK1)-induced unusual metabolism contribute to breast cancer progression and chemotherapy resistance. However, the role and mech...

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Veröffentlicht in:	Cancers 2022-07, Vol.14 (15), p.3600
Hauptverfasser:	Xie, Yunxia, Shi, Zhumei, Qian, Yingchen, Jiang, Chengfei, Liu, Wenjing, Liu, Bingjie, Jiang, Binghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Breast cancer Cancer therapies Chemoresistance Chemotherapy Correlation analysis Dehydrogenases DNMT1 protein Enzymes Epigenetics Flow cytometry Gene expression Gene set enrichment analysis Glucose Glucose metabolism Glycolysis HDAC2 protein Histone deacetylase Immunofluorescence Immunoprecipitation Kinases Mesenchyme Metastasis Morbidity Plasmids Post-transcription Proteins Pyruvic acid Tumors Western blotting
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