In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals
Background/Objectives Low-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and th...
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| Veröffentlicht in: | International Journal of Obesity 2022-08, Vol.46 (8), p.1435-1445 |
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| container_title | International Journal of Obesity |
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| creator | Huang, Wanyu Igusa, Tak Wang, Guoying Buckley, Jessie P. Hong, Xiumei Bind, Eric Steffens, Andrew Mukherjee, Jhindan Haltmeier, Douglas Ji, Yuelong Xu, Richard Hou, Wenpin (Tina) Fan, Zhihua Wang, Xiaobin |
| description | Background/Objectives
Low-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and the lack of intervention strategy, we aimed to investigate the association between in-utero co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and whether adequate maternal micronutrients (selenium (Se) and folate) can be protective.
Subjects/Methods
This study included 1442 mother-child pairs from the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic population, who were enrolled at birth and followed prospectively up to age 15 years. Bayesian kernel machine regression (BKMR) was applied to estimate individual and joint effects of exposures to metals and micronutrients on childhood OWO while adjusting for pertinent covariables. Stratified analyses by maternal OWO and micronutrient status were performed to identify sensitive subgroups.
Results
In this sample of understudied US children, low-level in-utero co-exposure to Hg, Pb, and Cd was widespread. Besides individual positive associations of maternal Hg and Pb exposure with offspring OWO, BKMR clearly indicated a positive dose-response association between in-utero co-exposure to the three toxic metals and childhood OWO. Notably, the metal mixture-OWO association was more pronounced in children born to mothers with OWO; and in such a setting, the association was greatly attenuated if mothers had higher Se and folate levels.
Conclusions
In this prospective cohort of US children at high-risk of toxic metal exposure and OWO, we demonstrated that among children born to mothers with OWO, low-level in-utero co-exposure to Hg, Pb, and Cd increased the risk of childhood OWO; and that adequate maternal Se and folate levels mitigated the risk of childhood OWO.
Clinical Trial Registry number and website where it was obtained
NCT03228875 |
| doi_str_mv | 10.1038/s41366-022-01127-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9329205</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2694115978</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-13a5b339901b91644e254281067a2bc743105e9c3f6b0c0898f73d8c983a8ae73</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhoMo9lr9Ay4k4MZNNN-ZuBBK8aNQcKPrkMlk7k2dSa5Jpr39L_5Yo1Or7UIIHMh58p735AXgOcGvCWbdm8IJkxJhShEmhCp0eAA2hCuJBNfqIdhghhXCQooj8KSUC4yxEJg-BkdMiE5rSTfgx1lES_U5QZeQP-xTWbKHNbVzCA7OvtqpQBsHOAeXU1xqDj7WAlOEbhemYZfSAHMo32AaYbr0-cqH7a7ClGHqfQn1-i2M_gqGWNb7eF_JpSU2B9bVELd35j4Fj8ZW_LObegy-fnj_5fQTOv_88ez05Bw5rnhFhFnRM6Y1Jr0mknNPBacdwVJZ2jvFGcHCa8dG2WOHO92Nig2d0x2znfWKHYN3q-5-6Wc_uGYr28nsc5htvjbJBnO3E8PObNOl0YxqikUTeHUjkNP3xZdq5lCcnyYbfVqKoVIq1exR3tCX99CLtOTY1muU5oQIrbpG0ZVqP1VK9uOtGYLNr_DNGr5p4Zvf4ZtDe_Ti3zVun_xJuwFsBUprxa3Pf2f_R_Yn5oy_MA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2694115978</pqid></control><display><type>article</type><title>In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals</title><source>MEDLINE</source><source>Nature Journals Online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Huang, Wanyu ; Igusa, Tak ; Wang, Guoying ; Buckley, Jessie P. ; Hong, Xiumei ; Bind, Eric ; Steffens, Andrew ; Mukherjee, Jhindan ; Haltmeier, Douglas ; Ji, Yuelong ; Xu, Richard ; Hou, Wenpin ; (Tina) Fan, Zhihua ; Wang, Xiaobin</creator><creatorcontrib>Huang, Wanyu ; Igusa, Tak ; Wang, Guoying ; Buckley, Jessie P. ; Hong, Xiumei ; Bind, Eric ; Steffens, Andrew ; Mukherjee, Jhindan ; Haltmeier, Douglas ; Ji, Yuelong ; Xu, Richard ; Hou, Wenpin ; (Tina) Fan, Zhihua ; Wang, Xiaobin</creatorcontrib><description>Background/Objectives
Low-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and the lack of intervention strategy, we aimed to investigate the association between in-utero co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and whether adequate maternal micronutrients (selenium (Se) and folate) can be protective.
Subjects/Methods
This study included 1442 mother-child pairs from the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic population, who were enrolled at birth and followed prospectively up to age 15 years. Bayesian kernel machine regression (BKMR) was applied to estimate individual and joint effects of exposures to metals and micronutrients on childhood OWO while adjusting for pertinent covariables. Stratified analyses by maternal OWO and micronutrient status were performed to identify sensitive subgroups.
Results
In this sample of understudied US children, low-level in-utero co-exposure to Hg, Pb, and Cd was widespread. Besides individual positive associations of maternal Hg and Pb exposure with offspring OWO, BKMR clearly indicated a positive dose-response association between in-utero co-exposure to the three toxic metals and childhood OWO. Notably, the metal mixture-OWO association was more pronounced in children born to mothers with OWO; and in such a setting, the association was greatly attenuated if mothers had higher Se and folate levels.
Conclusions
In this prospective cohort of US children at high-risk of toxic metal exposure and OWO, we demonstrated that among children born to mothers with OWO, low-level in-utero co-exposure to Hg, Pb, and Cd increased the risk of childhood OWO; and that adequate maternal Se and folate levels mitigated the risk of childhood OWO.
Clinical Trial Registry number and website where it was obtained
NCT03228875</description><identifier>ISSN: 0307-0565</identifier><identifier>ISSN: 1476-5497</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-022-01127-x</identifier><identifier>PMID: 35589962</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/92/321 ; 692/308/174 ; 692/499 ; 692/700/2814 ; 692/700/459/1994 ; Adolescent ; Bayes Theorem ; Bayesian analysis ; Body weight ; Cadmium ; Cadmium - toxicity ; Child ; Child, Preschool ; Childhood ; Children ; Epidemiology ; Exposure ; Female ; Folic Acid ; Health Promotion and Disease Prevention ; Heavy metals ; Humans ; Infant ; Infant, Newborn ; Internal Medicine ; Intrauterine exposure ; Lead ; Lead - toxicity ; Medicine ; Medicine & Public Health ; Mercury ; Mercury (metal) ; Mercury - toxicity ; Metabolic Diseases ; Metals ; Metals - toxicity ; Micronutrients ; Mothers ; Obesity ; Offspring ; Overweight ; Overweight - epidemiology ; Pediatric Obesity - epidemiology ; Pregnancy ; Prenatal Exposure Delayed Effects - epidemiology ; Prospective Studies ; Public Health ; Risk ; Risk reduction ; Selenium ; Subgroups ; Vitamin B ; Websites</subject><ispartof>International Journal of Obesity, 2022-08, Vol.46 (8), p.1435-1445</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-13a5b339901b91644e254281067a2bc743105e9c3f6b0c0898f73d8c983a8ae73</citedby><cites>FETCH-LOGICAL-c474t-13a5b339901b91644e254281067a2bc743105e9c3f6b0c0898f73d8c983a8ae73</cites><orcidid>0000-0003-3074-2833 ; 0000-0003-4451-302X ; 0000-0002-7276-5892</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41366-022-01127-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41366-022-01127-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35589962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Wanyu</creatorcontrib><creatorcontrib>Igusa, Tak</creatorcontrib><creatorcontrib>Wang, Guoying</creatorcontrib><creatorcontrib>Buckley, Jessie P.</creatorcontrib><creatorcontrib>Hong, Xiumei</creatorcontrib><creatorcontrib>Bind, Eric</creatorcontrib><creatorcontrib>Steffens, Andrew</creatorcontrib><creatorcontrib>Mukherjee, Jhindan</creatorcontrib><creatorcontrib>Haltmeier, Douglas</creatorcontrib><creatorcontrib>Ji, Yuelong</creatorcontrib><creatorcontrib>Xu, Richard</creatorcontrib><creatorcontrib>Hou, Wenpin</creatorcontrib><creatorcontrib>(Tina) Fan, Zhihua</creatorcontrib><creatorcontrib>Wang, Xiaobin</creatorcontrib><title>In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background/Objectives
Low-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and the lack of intervention strategy, we aimed to investigate the association between in-utero co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and whether adequate maternal micronutrients (selenium (Se) and folate) can be protective.
Subjects/Methods
This study included 1442 mother-child pairs from the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic population, who were enrolled at birth and followed prospectively up to age 15 years. Bayesian kernel machine regression (BKMR) was applied to estimate individual and joint effects of exposures to metals and micronutrients on childhood OWO while adjusting for pertinent covariables. Stratified analyses by maternal OWO and micronutrient status were performed to identify sensitive subgroups.
Results
In this sample of understudied US children, low-level in-utero co-exposure to Hg, Pb, and Cd was widespread. Besides individual positive associations of maternal Hg and Pb exposure with offspring OWO, BKMR clearly indicated a positive dose-response association between in-utero co-exposure to the three toxic metals and childhood OWO. Notably, the metal mixture-OWO association was more pronounced in children born to mothers with OWO; and in such a setting, the association was greatly attenuated if mothers had higher Se and folate levels.
Conclusions
In this prospective cohort of US children at high-risk of toxic metal exposure and OWO, we demonstrated that among children born to mothers with OWO, low-level in-utero co-exposure to Hg, Pb, and Cd increased the risk of childhood OWO; and that adequate maternal Se and folate levels mitigated the risk of childhood OWO.
Clinical Trial Registry number and website where it was obtained
NCT03228875</description><subject>631/92/321</subject><subject>692/308/174</subject><subject>692/499</subject><subject>692/700/2814</subject><subject>692/700/459/1994</subject><subject>Adolescent</subject><subject>Bayes Theorem</subject><subject>Bayesian analysis</subject><subject>Body weight</subject><subject>Cadmium</subject><subject>Cadmium - toxicity</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Female</subject><subject>Folic Acid</subject><subject>Health Promotion and Disease Prevention</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Internal Medicine</subject><subject>Intrauterine exposure</subject><subject>Lead</subject><subject>Lead - toxicity</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mercury</subject><subject>Mercury (metal)</subject><subject>Mercury - toxicity</subject><subject>Metabolic Diseases</subject><subject>Metals</subject><subject>Metals - toxicity</subject><subject>Micronutrients</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Offspring</subject><subject>Overweight</subject><subject>Overweight - epidemiology</subject><subject>Pediatric Obesity - epidemiology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Risk</subject><subject>Risk reduction</subject><subject>Selenium</subject><subject>Subgroups</subject><subject>Vitamin B</subject><subject>Websites</subject><issn>0307-0565</issn><issn>1476-5497</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1rFTEUhoMo9lr9Ay4k4MZNNN-ZuBBK8aNQcKPrkMlk7k2dSa5Jpr39L_5Yo1Or7UIIHMh58p735AXgOcGvCWbdm8IJkxJhShEmhCp0eAA2hCuJBNfqIdhghhXCQooj8KSUC4yxEJg-BkdMiE5rSTfgx1lES_U5QZeQP-xTWbKHNbVzCA7OvtqpQBsHOAeXU1xqDj7WAlOEbhemYZfSAHMo32AaYbr0-cqH7a7ClGHqfQn1-i2M_gqGWNb7eF_JpSU2B9bVELd35j4Fj8ZW_LObegy-fnj_5fQTOv_88ez05Bw5rnhFhFnRM6Y1Jr0mknNPBacdwVJZ2jvFGcHCa8dG2WOHO92Nig2d0x2znfWKHYN3q-5-6Wc_uGYr28nsc5htvjbJBnO3E8PObNOl0YxqikUTeHUjkNP3xZdq5lCcnyYbfVqKoVIq1exR3tCX99CLtOTY1muU5oQIrbpG0ZVqP1VK9uOtGYLNr_DNGr5p4Zvf4ZtDe_Ti3zVun_xJuwFsBUprxa3Pf2f_R_Yn5oy_MA</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Huang, Wanyu</creator><creator>Igusa, Tak</creator><creator>Wang, Guoying</creator><creator>Buckley, Jessie P.</creator><creator>Hong, Xiumei</creator><creator>Bind, Eric</creator><creator>Steffens, Andrew</creator><creator>Mukherjee, Jhindan</creator><creator>Haltmeier, Douglas</creator><creator>Ji, Yuelong</creator><creator>Xu, Richard</creator><creator>Hou, Wenpin</creator><creator>(Tina) Fan, Zhihua</creator><creator>Wang, Xiaobin</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3074-2833</orcidid><orcidid>https://orcid.org/0000-0003-4451-302X</orcidid><orcidid>https://orcid.org/0000-0002-7276-5892</orcidid></search><sort><creationdate>20220801</creationdate><title>In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals</title><author>Huang, Wanyu ; Igusa, Tak ; Wang, Guoying ; Buckley, Jessie P. ; Hong, Xiumei ; Bind, Eric ; Steffens, Andrew ; Mukherjee, Jhindan ; Haltmeier, Douglas ; Ji, Yuelong ; Xu, Richard ; Hou, Wenpin ; (Tina) Fan, Zhihua ; Wang, Xiaobin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-13a5b339901b91644e254281067a2bc743105e9c3f6b0c0898f73d8c983a8ae73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>631/92/321</topic><topic>692/308/174</topic><topic>692/499</topic><topic>692/700/2814</topic><topic>692/700/459/1994</topic><topic>Adolescent</topic><topic>Bayes Theorem</topic><topic>Bayesian analysis</topic><topic>Body weight</topic><topic>Cadmium</topic><topic>Cadmium - toxicity</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Female</topic><topic>Folic Acid</topic><topic>Health Promotion and Disease Prevention</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Internal Medicine</topic><topic>Intrauterine exposure</topic><topic>Lead</topic><topic>Lead - toxicity</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mercury</topic><topic>Mercury (metal)</topic><topic>Mercury - toxicity</topic><topic>Metabolic Diseases</topic><topic>Metals</topic><topic>Metals - toxicity</topic><topic>Micronutrients</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Offspring</topic><topic>Overweight</topic><topic>Overweight - epidemiology</topic><topic>Pediatric Obesity - epidemiology</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Risk</topic><topic>Risk reduction</topic><topic>Selenium</topic><topic>Subgroups</topic><topic>Vitamin B</topic><topic>Websites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Wanyu</creatorcontrib><creatorcontrib>Igusa, Tak</creatorcontrib><creatorcontrib>Wang, Guoying</creatorcontrib><creatorcontrib>Buckley, Jessie P.</creatorcontrib><creatorcontrib>Hong, Xiumei</creatorcontrib><creatorcontrib>Bind, Eric</creatorcontrib><creatorcontrib>Steffens, Andrew</creatorcontrib><creatorcontrib>Mukherjee, Jhindan</creatorcontrib><creatorcontrib>Haltmeier, Douglas</creatorcontrib><creatorcontrib>Ji, Yuelong</creatorcontrib><creatorcontrib>Xu, Richard</creatorcontrib><creatorcontrib>Hou, Wenpin</creatorcontrib><creatorcontrib>(Tina) Fan, Zhihua</creatorcontrib><creatorcontrib>Wang, Xiaobin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Wanyu</au><au>Igusa, Tak</au><au>Wang, Guoying</au><au>Buckley, Jessie P.</au><au>Hong, Xiumei</au><au>Bind, Eric</au><au>Steffens, Andrew</au><au>Mukherjee, Jhindan</au><au>Haltmeier, Douglas</au><au>Ji, Yuelong</au><au>Xu, Richard</au><au>Hou, Wenpin</au><au>(Tina) Fan, Zhihua</au><au>Wang, Xiaobin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>46</volume><issue>8</issue><spage>1435</spage><epage>1445</epage><pages>1435-1445</pages><issn>0307-0565</issn><issn>1476-5497</issn><eissn>1476-5497</eissn><abstract>Background/Objectives
Low-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and the lack of intervention strategy, we aimed to investigate the association between in-utero co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and whether adequate maternal micronutrients (selenium (Se) and folate) can be protective.
Subjects/Methods
This study included 1442 mother-child pairs from the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic population, who were enrolled at birth and followed prospectively up to age 15 years. Bayesian kernel machine regression (BKMR) was applied to estimate individual and joint effects of exposures to metals and micronutrients on childhood OWO while adjusting for pertinent covariables. Stratified analyses by maternal OWO and micronutrient status were performed to identify sensitive subgroups.
Results
In this sample of understudied US children, low-level in-utero co-exposure to Hg, Pb, and Cd was widespread. Besides individual positive associations of maternal Hg and Pb exposure with offspring OWO, BKMR clearly indicated a positive dose-response association between in-utero co-exposure to the three toxic metals and childhood OWO. Notably, the metal mixture-OWO association was more pronounced in children born to mothers with OWO; and in such a setting, the association was greatly attenuated if mothers had higher Se and folate levels.
Conclusions
In this prospective cohort of US children at high-risk of toxic metal exposure and OWO, we demonstrated that among children born to mothers with OWO, low-level in-utero co-exposure to Hg, Pb, and Cd increased the risk of childhood OWO; and that adequate maternal Se and folate levels mitigated the risk of childhood OWO.
Clinical Trial Registry number and website where it was obtained
NCT03228875</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35589962</pmid><doi>10.1038/s41366-022-01127-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3074-2833</orcidid><orcidid>https://orcid.org/0000-0003-4451-302X</orcidid><orcidid>https://orcid.org/0000-0002-7276-5892</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2022-08, Vol.46 (8), p.1435-1445 |
| issn | 0307-0565 1476-5497 1476-5497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9329205 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 631/92/321 692/308/174 692/499 692/700/2814 692/700/459/1994 Adolescent Bayes Theorem Bayesian analysis Body weight Cadmium Cadmium - toxicity Child Child, Preschool Childhood Children Epidemiology Exposure Female Folic Acid Health Promotion and Disease Prevention Heavy metals Humans Infant Infant, Newborn Internal Medicine Intrauterine exposure Lead Lead - toxicity Medicine Medicine & Public Health Mercury Mercury (metal) Mercury - toxicity Metabolic Diseases Metals Metals - toxicity Micronutrients Mothers Obesity Offspring Overweight Overweight - epidemiology Pediatric Obesity - epidemiology Pregnancy Prenatal Exposure Delayed Effects - epidemiology Prospective Studies Public Health Risk Risk reduction Selenium Subgroups Vitamin B Websites |
| title | In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T23%3A02%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In-utero%20co-exposure%20to%20toxic%20metals%20and%20micronutrients%20on%20childhood%20risk%20of%20overweight%20or%20obesity:%20new%20insight%20on%20micronutrients%20counteracting%20toxic%20metals&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Huang,%20Wanyu&rft.date=2022-08-01&rft.volume=46&rft.issue=8&rft.spage=1435&rft.epage=1445&rft.pages=1435-1445&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/s41366-022-01127-x&rft_dat=%3Cproquest_pubme%3E2694115978%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2694115978&rft_id=info:pmid/35589962&rfr_iscdi=true |