Myeloma Cells Down‐Regulate Adiponectin in Bone Marrow Adipocytes Via TNF‐Alpha

ABSTRACT Multiple myeloma is caused by abnormal plasma cells that accumulate in the bone marrow and interact with resident cells of the bone microenvironment to drive disease progression and development of an osteolytic bone disease. Bone marrow adipocytes (BMAds) are emerging as having important en...

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Veröffentlicht in:	Journal of bone and mineral research 2020-05, Vol.35 (5), p.942-955
Hauptverfasser:	Morris, Emma V, Suchacki, Karla J, Hocking, Joseph, Cartwright, Rachel, Sowman, Aneka, Gamez, Beatriz, Lea, Ryan, Drake, Matthew T, Cawthorn, William P, Edwards, Claire M
Format:	Artikel
Sprache:	eng
Schlagworte:	ADIPOCYTE Adipocytes ADIPONECTIN Adipose tissue Animal models Apoptosis Bone diseases Bone marrow BONE MARROW ADIPOSE TISSUE CANCER Cell adhesion & migration Cell growth Cell migration Cell survival Lipids MULTIPLE MYELOMA Original Osteolysis Plasma cells Tumor cells Tumor necrosis factor
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