Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice
ABSTRACT Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However, the effect vitamin D supplements have on skeletal muscle health is equivocal. Although vitamin D is known to play a role in the various processes that maintain muscle integrity and function, recen...
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creator | Debruin, Danielle A Timpani, Cara A Lalunio, Hannah Rybalka, Emma Goodman, Craig A Hayes, Alan |
description | ABSTRACT
Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However, the effect vitamin D supplements have on skeletal muscle health is equivocal. Although vitamin D is known to play a role in the various processes that maintain muscle integrity and function, recent studies utilizing high bolus dose vitamin D supplementation has demonstrated an increased risk of falls. Thus, the aim of this study was to investigate the effects of high vitamin D supplementation on skeletal muscle function with and without exercise enrichment. Four‐week old C57BL/10 mice (n = 48) were separated into either normal vitamin D (1500 IU/kg diet; unsupplemented) or high vitamin D (20,000 IU/kg diet; supplemented) treatment groups. Each dietary group was further separated into interventional subgroups where mice either remained sedentary or received exercise‐enrichment for 8 weeks in the form of voluntary running. Following the intervention period, whole body in vivo and ex vivo contractile analysis were performed. High vitamin D supplementation decreased force production in the slow‐twitch soleus muscles of sedentary mice (p < .01); however, exercise normalized this effect. Eight weeks of exercise did not improve fatigue resistance of the extensor digitorum longus (EDL) or soleus muscles in unsupplemented mice, likely due to low levels of activation in these muscles. In contrast, fatigability was improved in the EDL (p < .01) and even more so in the soleus (p < .001) in the supplemented exercise‐enriched group. Our data highlights that increasing vitamin D levels above normal reduces postural muscle force as seen in the soleus. Thus, unnecessary vitamin D supplementation may contribute to the increased risk of falls observed in some studies. Interestingly, when vitamin D supplementation was combined with exercise, force production was effectively restored, and fatigue resistance improved, even in muscles lowly activated. Regular exercise may modulate the effects of vitamin D on skeletal muscle, and be recommended for individuals receiving vitamin D supplements. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research. |
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Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However, the effect vitamin D supplements have on skeletal muscle health is equivocal. Although vitamin D is known to play a role in the various processes that maintain muscle integrity and function, recent studies utilizing high bolus dose vitamin D supplementation has demonstrated an increased risk of falls. Thus, the aim of this study was to investigate the effects of high vitamin D supplementation on skeletal muscle function with and without exercise enrichment. Four‐week old C57BL/10 mice (n = 48) were separated into either normal vitamin D (1500 IU/kg diet; unsupplemented) or high vitamin D (20,000 IU/kg diet; supplemented) treatment groups. Each dietary group was further separated into interventional subgroups where mice either remained sedentary or received exercise‐enrichment for 8 weeks in the form of voluntary running. Following the intervention period, whole body in vivo and ex vivo contractile analysis were performed. High vitamin D supplementation decreased force production in the slow‐twitch soleus muscles of sedentary mice (p < .01); however, exercise normalized this effect. Eight weeks of exercise did not improve fatigue resistance of the extensor digitorum longus (EDL) or soleus muscles in unsupplemented mice, likely due to low levels of activation in these muscles. In contrast, fatigability was improved in the EDL (p < .01) and even more so in the soleus (p < .001) in the supplemented exercise‐enriched group. Our data highlights that increasing vitamin D levels above normal reduces postural muscle force as seen in the soleus. Thus, unnecessary vitamin D supplementation may contribute to the increased risk of falls observed in some studies. Interestingly, when vitamin D supplementation was combined with exercise, force production was effectively restored, and fatigue resistance improved, even in muscles lowly activated. Regular exercise may modulate the effects of vitamin D on skeletal muscle, and be recommended for individuals receiving vitamin D supplements. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1002/jbmr.3985</identifier><identifier>PMID: 32078180</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>CHOLECALCIFEROL ; Dietary supplements ; Fatigue ; MITOCHONDRIA ; Muscle contraction ; MUSCLE FATIGUE ; MUSCLE FUNCTION ; Musculoskeletal system ; Original ; Osteoporosis ; Physical training ; Side effects ; Skeletal muscle ; VITAMIN D ; VOLUNTARY RUNNING</subject><ispartof>Journal of bone and mineral research, 2020-06, Vol.35 (6), p.1092-1106</ispartof><rights>2020 The Authors. published by American Society for Bone and Mineral Research.</rights><rights>2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5095-c66d396b1397c60bca2da7ef7571a9d880f4b0f2e6c22aeade3fea0ad3b324893</citedby><cites>FETCH-LOGICAL-c5095-c66d396b1397c60bca2da7ef7571a9d880f4b0f2e6c22aeade3fea0ad3b324893</cites><orcidid>0000-0003-1398-3694</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbmr.3985$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbmr.3985$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32078180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Debruin, Danielle A</creatorcontrib><creatorcontrib>Timpani, Cara A</creatorcontrib><creatorcontrib>Lalunio, Hannah</creatorcontrib><creatorcontrib>Rybalka, Emma</creatorcontrib><creatorcontrib>Goodman, Craig A</creatorcontrib><creatorcontrib>Hayes, Alan</creatorcontrib><title>Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>ABSTRACT
Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However, the effect vitamin D supplements have on skeletal muscle health is equivocal. Although vitamin D is known to play a role in the various processes that maintain muscle integrity and function, recent studies utilizing high bolus dose vitamin D supplementation has demonstrated an increased risk of falls. Thus, the aim of this study was to investigate the effects of high vitamin D supplementation on skeletal muscle function with and without exercise enrichment. Four‐week old C57BL/10 mice (n = 48) were separated into either normal vitamin D (1500 IU/kg diet; unsupplemented) or high vitamin D (20,000 IU/kg diet; supplemented) treatment groups. Each dietary group was further separated into interventional subgroups where mice either remained sedentary or received exercise‐enrichment for 8 weeks in the form of voluntary running. Following the intervention period, whole body in vivo and ex vivo contractile analysis were performed. High vitamin D supplementation decreased force production in the slow‐twitch soleus muscles of sedentary mice (p < .01); however, exercise normalized this effect. Eight weeks of exercise did not improve fatigue resistance of the extensor digitorum longus (EDL) or soleus muscles in unsupplemented mice, likely due to low levels of activation in these muscles. In contrast, fatigability was improved in the EDL (p < .01) and even more so in the soleus (p < .001) in the supplemented exercise‐enriched group. Our data highlights that increasing vitamin D levels above normal reduces postural muscle force as seen in the soleus. Thus, unnecessary vitamin D supplementation may contribute to the increased risk of falls observed in some studies. Interestingly, when vitamin D supplementation was combined with exercise, force production was effectively restored, and fatigue resistance improved, even in muscles lowly activated. Regular exercise may modulate the effects of vitamin D on skeletal muscle, and be recommended for individuals receiving vitamin D supplements. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.</description><subject>CHOLECALCIFEROL</subject><subject>Dietary supplements</subject><subject>Fatigue</subject><subject>MITOCHONDRIA</subject><subject>Muscle contraction</subject><subject>MUSCLE FATIGUE</subject><subject>MUSCLE FUNCTION</subject><subject>Musculoskeletal system</subject><subject>Original</subject><subject>Osteoporosis</subject><subject>Physical training</subject><subject>Side effects</subject><subject>Skeletal muscle</subject><subject>VITAMIN D</subject><subject>VOLUNTARY RUNNING</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kV1rFDEUhoModq1e-Ack4I1eTHuSTCaZG6EfW6t0Eax6GzKZM90sM5NtMmO7_97Z3VpUEA4ETh4e3sNLyGsGRwyAH6-qLh6JUssnZMYkF1leaPaUzEDrPINcsAPyIqUVABSyKJ6TA8FBaaZhRm7n9xidT0gXdkNPOmx9iHZAOiyRnuMQfYf9YFt67Wuk86ZBNyQaGnrpb5b0hx9s53t6Tq_H9brFHTv40NNpFmNyLdKLsXe71cQtvMOX5Flj24SvHt5D8v1i_u3sMrv68vHT2clV5iSUMnNFUYuyqJgolSugcpbXVmGjpGK2rLWGJq-g4Vg4zi3aGkWDFmwtKsFzXYpD8mHvXY9Vh7WbokXbmvV0kY0bE6w3f__0fmluwk9TCq4UV5Pg3YMghtsR02A6nxy2re0xjMlwIctcyBy26Nt_0FUYYz-dZ3jOuGISRD5R7_eUiyGliM1jGAZmW6TZFmm2RU7smz_TP5K_m5uA4z1w51vc_N9kPp8uvu6UvwBRHKnA</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Debruin, Danielle A</creator><creator>Timpani, Cara A</creator><creator>Lalunio, Hannah</creator><creator>Rybalka, Emma</creator><creator>Goodman, Craig A</creator><creator>Hayes, Alan</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1398-3694</orcidid></search><sort><creationdate>202006</creationdate><title>Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice</title><author>Debruin, Danielle A ; Timpani, Cara A ; Lalunio, Hannah ; Rybalka, Emma ; Goodman, Craig A ; Hayes, Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5095-c66d396b1397c60bca2da7ef7571a9d880f4b0f2e6c22aeade3fea0ad3b324893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>CHOLECALCIFEROL</topic><topic>Dietary supplements</topic><topic>Fatigue</topic><topic>MITOCHONDRIA</topic><topic>Muscle contraction</topic><topic>MUSCLE FATIGUE</topic><topic>MUSCLE FUNCTION</topic><topic>Musculoskeletal system</topic><topic>Original</topic><topic>Osteoporosis</topic><topic>Physical training</topic><topic>Side effects</topic><topic>Skeletal muscle</topic><topic>VITAMIN D</topic><topic>VOLUNTARY RUNNING</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Debruin, Danielle A</creatorcontrib><creatorcontrib>Timpani, Cara A</creatorcontrib><creatorcontrib>Lalunio, Hannah</creatorcontrib><creatorcontrib>Rybalka, Emma</creatorcontrib><creatorcontrib>Goodman, Craig A</creatorcontrib><creatorcontrib>Hayes, Alan</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Debruin, Danielle A</au><au>Timpani, Cara A</au><au>Lalunio, Hannah</au><au>Rybalka, Emma</au><au>Goodman, Craig A</au><au>Hayes, Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2020-06</date><risdate>2020</risdate><volume>35</volume><issue>6</issue><spage>1092</spage><epage>1106</epage><pages>1092-1106</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><abstract>ABSTRACT
Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However, the effect vitamin D supplements have on skeletal muscle health is equivocal. Although vitamin D is known to play a role in the various processes that maintain muscle integrity and function, recent studies utilizing high bolus dose vitamin D supplementation has demonstrated an increased risk of falls. Thus, the aim of this study was to investigate the effects of high vitamin D supplementation on skeletal muscle function with and without exercise enrichment. Four‐week old C57BL/10 mice (n = 48) were separated into either normal vitamin D (1500 IU/kg diet; unsupplemented) or high vitamin D (20,000 IU/kg diet; supplemented) treatment groups. Each dietary group was further separated into interventional subgroups where mice either remained sedentary or received exercise‐enrichment for 8 weeks in the form of voluntary running. Following the intervention period, whole body in vivo and ex vivo contractile analysis were performed. High vitamin D supplementation decreased force production in the slow‐twitch soleus muscles of sedentary mice (p < .01); however, exercise normalized this effect. Eight weeks of exercise did not improve fatigue resistance of the extensor digitorum longus (EDL) or soleus muscles in unsupplemented mice, likely due to low levels of activation in these muscles. In contrast, fatigability was improved in the EDL (p < .01) and even more so in the soleus (p < .001) in the supplemented exercise‐enriched group. Our data highlights that increasing vitamin D levels above normal reduces postural muscle force as seen in the soleus. Thus, unnecessary vitamin D supplementation may contribute to the increased risk of falls observed in some studies. Interestingly, when vitamin D supplementation was combined with exercise, force production was effectively restored, and fatigue resistance improved, even in muscles lowly activated. Regular exercise may modulate the effects of vitamin D on skeletal muscle, and be recommended for individuals receiving vitamin D supplements. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32078180</pmid><doi>10.1002/jbmr.3985</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-1398-3694</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | CHOLECALCIFEROL Dietary supplements Fatigue MITOCHONDRIA Muscle contraction MUSCLE FATIGUE MUSCLE FUNCTION Musculoskeletal system Original Osteoporosis Physical training Side effects Skeletal muscle VITAMIN D VOLUNTARY RUNNING |
title | Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice |
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