Non‐psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors‐, endocannabinoids‐, and NF‐κB‐mediated signaling

Cannabis sativa L. is increasingly emerging for its protective role in modulating neuroinflammation, a complex process orchestrated among others by microglia, the resident immune cells of the central nervous system. Phytocannabinoids, especially cannabidiol (CBD), terpenes, and other constituents tr...

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Veröffentlicht in:	Phytotherapy research 2022-05, Vol.36 (5), p.2246-2263
Hauptverfasser:	Borgonetti, Vittoria, Benatti, Cristina, Governa, Paolo, Isoldi, Giovanni, Pellati, Federica, Alboni, Silvia, Tascedda, Fabio, Montopoli, Monica, Galeotti, Nicoletta, Manetti, Fabrizio, Miraldi, Elisabetta, Biagi, Marco, Rigillo, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Cannabidiol Cannabinoid CB2 receptors Cannabinoids Cannabis Cannabis sativa Cannabis sativa L Caryophyllene Central nervous system Cytokines Immune system Inflammation Inflammatory response Interleukin 6 Lipopolysaccharides Metabolism Microglia Modulation Molecular modelling Nuclear transport phytocomplex Reactive oxygen species Receptors Terpenes Translocation Tumor necrosis factor β‐Caryophyllene
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