Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity

Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity

From the dried vines of Aspidopterys obcordata Hemsl, five new polyoxypregnane glycosides, named obcordatas J–N (1–5), were obtained. Their structures were fully elucidated and characterized by HRESIMS and extensive spectroscopic data. In addition, all of the new compounds were screened for their an...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2022-07, Vol.27 (14), p.4596
Hauptverfasser: Sun, Zhaocui, Chen, Meiying, Li, Qinglong, Ma, Guoxu, Wu, Haifeng, Yang, Junshan, Li, Yihang, Xu, Xudong
Format: Artikel
Sprache:eng
Schlagworte:
Calcium compounds
Calcium oxalate
Glycosides
Kidney stones
Kidneys
Nephrolithiasis
Oxalic acid
Vines
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Zusammenfassung:From the dried vines of Aspidopterys obcordata Hemsl, five new polyoxypregnane glycosides, named obcordatas J–N (1–5), were obtained. Their structures were fully elucidated and characterized by HRESIMS and extensive spectroscopic data. In addition, all of the new compounds were screened for their antinephrolithiasis activity in vitro. The results showed that compounds 1–3 have prominent protective effects on calcium oxalate crystal-induced human kidney 2 (HK-2) cells, with EC50 values ranging from 6.72 to 14.00 μM, which is consistent with the application value of A. obcordata in folk medicine for kidney stones.
ISSN:1420-3049
DOI:10.3390/molecules27144596