A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer

Overcoming resistance is one of the most challenging features in current anticancer therapy. Autophagy is a cellular process that confers resistance in some advanced tumors, since it enables cancer cells to adapt to stressful situations, such as anticancer treatments. Hence, the inhibition of this c...

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Veröffentlicht in:	Cancers 2022-07, Vol.14 (14), p.3387
Hauptverfasser:	Molero-Valenzuela, Adrià, Fontova, Pere, Alonso-Carrillo, Daniel, Carreira-Barral, Israel, Torres, Ana Aurora, García-Valverde, María, Benítez-García, Cristina, Pérez-Tomás, Ricardo, Quesada, Roberto, Soto-Cerrato, Vanessa
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Aqueous solutions Autophagy Autophagy (Cytology) Cancer Cancer therapies Care and treatment Caspase-3 Cell death Cell fusion Chemotherapy Chloride Chloroquine Cisplatin Cytotoxicity Development and progression Experiments Fluorides Health aspects LAMP-1 protein Lung cancer Lysosomes Medical prognosis Patient outcomes Phagosomes Poly(ADP-ribose) polymerase Proteins Therapeutic applications Tumor cell lines Tumor cells Tumors
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