Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis
Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancer...
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| Veröffentlicht in: | Cancers 2022-07, Vol.14 (14), p.3547 |
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| container_title | Cancers |
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| creator | LIU, Jiaqi LEUNG, Chi Tim LIANG, Luyun WANG, Yuqin CHEN, Jian LAI, Keng Po TSE, William Ka Fai |
| description | Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers. |
| doi_str_mv | 10.3390/cancers14143547 |
| format | Article |
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They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14143547</identifier><identifier>PMID: 35884607</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Apoptosis ; Breast ; Cell cycle ; Cell division ; Cell growth ; Cyclin-dependent kinases ; Enzymes ; Hepatitis ; Inflammation ; Kinases ; Liver ; Liver cancer ; Liver diseases ; Medical prognosis ; Metastases ; Metastasis ; Pancreas ; Prostate ; Proteins ; Review ; Roles ; Ubiquitin</subject><ispartof>Cancers, 2022-07, Vol.14 (14), p.3547</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Apoptosis Breast Cell cycle Cell division Cell growth Cyclin-dependent kinases Enzymes Hepatitis Inflammation Kinases Liver Liver cancer Liver diseases Medical prognosis Metastases Metastasis Pancreas Prostate Proteins Review Roles Ubiquitin |
| title | Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis |
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