Central Role of Semaphorin 3B in a Serum‐Induced Arthritis Model and Reduced Levels in Patients With Rheumatoid Arthritis

Objective Semaphorin 3B (Sema3B) decreases the migratory and invasive capacities of fibroblast‐like synoviocytes (FLS) in rheumatoid arthritis (RA) and suppresses expression of matrix metalloproteinases. We undertook this study to examine the role of Sema3B in a mouse model of arthritis and its expr...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2022-06, Vol.74 (6), p.972-983
Hauptverfasser:	Igea, Ana, Carvalheiro, Tiago, Malvar‐Fernández, Beatriz, Martinez‐Ramos, Sara, Rafael‐Vidal, Carlos, Niemantsverdriet, Ellis, Varadé, Jezabel, Fernández‐Carrera, Andrea, Jimenez, Norman, McGarry, Trudy, Rodriguez‐Trillo, Angela, Veale, Douglas, Fearon, Ursula, Conde, Carmen, Pego‐Reigosa, Jose M., González‐Fernández, África, Reedquist, Kris A., Radstake, Timothy R. D. J., Helm‐Van Mil, Annette, García, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthralgia Arthritis DNA-directed RNA polymerase Full Length Gene expression Gene sequencing Immunoblotting Inflammation Joint diseases Matrix metalloproteinase Matrix metalloproteinases Patients Polymerase chain reaction Rheumatoid Arthritis Synoviocytes
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