Ameliorative Effect of Citropten Isolated from Citrus aurantifolia Peel Extract as a Modulator of T Cell and Intestinal Epithelial Cell Activity in DSS-Induced Colitis

Citropten is a coumarin that is mainly found in fruits of Rutaceae trees, but its anti-inflammatory activities in colitis is still unknown. In this study, we investigated its attenuating effect of citropten isolated from extract on DSS-induced colitis through the modulation of the activity of T cell...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2022-07, Vol.27 (14), p.4633
Hauptverfasser:	Lee, Hyun-Su, Kim, Eun-Nam, Jeong, Gil-Saeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Binding sites Body weight Chronic illnesses Citrus aurantifolia Colitis Colitis - chemically induced Colitis - drug therapy Colitis - metabolism Colon - metabolism Coumarin Coumarins - pharmacology Cytokines Cytokines - metabolism Cytotoxicity Dextran Sulfate - adverse effects Disease Models, Animal Effector cells Epithelial cells Epithelial Cells - metabolism Epithelium Flow cytometry Homeostasis Inflammation Inflammatory bowel disease Intestine Lymphocytes Lymphocytes T MAP kinase Mice Mice, Inbred C57BL mRNA NF-κB protein Oral administration Phosphorylation Plant extracts Pretreatment Rutaceae Signal transduction T cell receptors T-Lymphocytes - metabolism Transcription factors
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