A ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a disease that remains refractory to existing treatments including the nucleoside analogue gemcitabine. In the current study we demonstrate that an organometallic nucleoside analogue, the ferronucleoside 1-(S,Rp), is cytotoxic in a panel of PDAC ce...

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Veröffentlicht in:	Metallomics 2022-07, Vol.14 (7)
Hauptverfasser:	Rana, Marium, Perotti, Alessio, Bisset, Lucy M, Smith, James D, Lamden, Emma, Khan, Zahra, Ismail, Media K, Ellis, Katherine, Armstrong, Katie A, Hodder, Samantha L, Bertoli, Cosetta, Meneguello, Leticia, de Bruin, Robertus A M, Morris, Joanna R, Romero-Canelon, Isolda, Tucker, James H R, Hodges, Nikolas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - metabolism DNA Damage DNA Replication DNA-Binding Proteins - metabolism Humans Metallocenes Nucleosides - pharmacology Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics S Phase Tumor Suppressor Protein p53 - metabolism
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