Mitochondrial Dysfunction Affects the Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis Differently
There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison of synovial mitochondrial derangements in these main arthritis forms is missing. A prospective clinical study was conducted on adult patien...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2022-07, Vol.23 (14), p.7553 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 14 |
| container_start_page | 7553 |
| container_title | International journal of molecular sciences |
| container_volume | 23 |
| creator | Jávor, Péter Mácsai, Attila Butt, Edina Baráth, Bálint Jász, Dávid Kurszán Horváth, Tamara Baráth, Bence Csonka, Ákos Török, László Varga, Endre Hartmann, Petra |
| description | There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison of synovial mitochondrial derangements in these main arthritis forms is missing. A prospective clinical study was conducted on adult patients undergoing knee surgery. Patients were allocated into RA and OA groups based on disease-specific clinical scores, while patients without arthritis served as controls. Synovial samples were subjected to high-resolution respirometry to analyze mitochondrial functions. From the total of 814 patients, 109 cases were enrolled into the study (24 RA, 47 OA, and 38 control patients) between 1 September 2019 and 31 December 2021. The decrease in complex I-linked respiration and dyscoupling of mitochondria were characteristics of RA patients, while both arthritis groups displayed reduced OxPhos activity compared to the control group. However, no significant difference was found in complex II-related activity between the OA and RA groups. The cytochrome C release and H2O2 formation were increased in both arthritis groups. Mitochondrial dysfunction was present in both arthritis groups; however, to a different extent. Consequently, mitochondrial protective agents may have major benefits for arthritis patients. Based on our current study, we recommend focusing on respiratory complex I in rheumatoid arthritis research. |
| doi_str_mv | 10.3390/ijms23147553 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9319158</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2694020221</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-2488919a2eddf942dee032957b8872f34dfdb2a690d173907fcbe629c51d96fc3</originalsourceid><addsrcrecordid>eNpdkclOHDEQhi2UKGy58QCWuOTAELvci32JNBpCgkQEguRsebzQHnXbxHaD5u1jBEKQU5WqvvprQ-iIklPGBPnqN1MGRpu-bdkO2qMNwIKQrv_wxt9F-zlvCAEGrfiEdlnLeScI3UP5ly9RDzGY5NWIz7bZzUEXHwNeOmd1ybgMFt9uQ3zw84Sjw9eqeBtq4tGXAd8Mdp5Uid7gZSpD8sVnrILBV7nYqF5DZ77KpVo3bg_RR6fGbD-_2AP05_z779XPxeXVj4vV8nKhGRdlAQ3nggoF1hgnGjDWEgai7dec9-BYY5xZg6p7GNrXS_ROr20HQrfUiM5pdoC-Pevez-vJGl2bJzXK--QnlbYyKi_fZ4If5F18kIJRQVteBb68CKT4d7a5yMlnbcdRBRvnLKETLYim411Fj_9DN3FOoa73RDUECACt1MkzpVPMOVn3Ogwl8umb8u032T80ipSR</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2694020221</pqid></control><display><type>article</type><title>Mitochondrial Dysfunction Affects the Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis Differently</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Jávor, Péter ; Mácsai, Attila ; Butt, Edina ; Baráth, Bálint ; Jász, Dávid Kurszán ; Horváth, Tamara ; Baráth, Bence ; Csonka, Ákos ; Török, László ; Varga, Endre ; Hartmann, Petra</creator><creatorcontrib>Jávor, Péter ; Mácsai, Attila ; Butt, Edina ; Baráth, Bálint ; Jász, Dávid Kurszán ; Horváth, Tamara ; Baráth, Bence ; Csonka, Ákos ; Török, László ; Varga, Endre ; Hartmann, Petra</creatorcontrib><description>There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison of synovial mitochondrial derangements in these main arthritis forms is missing. A prospective clinical study was conducted on adult patients undergoing knee surgery. Patients were allocated into RA and OA groups based on disease-specific clinical scores, while patients without arthritis served as controls. Synovial samples were subjected to high-resolution respirometry to analyze mitochondrial functions. From the total of 814 patients, 109 cases were enrolled into the study (24 RA, 47 OA, and 38 control patients) between 1 September 2019 and 31 December 2021. The decrease in complex I-linked respiration and dyscoupling of mitochondria were characteristics of RA patients, while both arthritis groups displayed reduced OxPhos activity compared to the control group. However, no significant difference was found in complex II-related activity between the OA and RA groups. The cytochrome C release and H2O2 formation were increased in both arthritis groups. Mitochondrial dysfunction was present in both arthritis groups; however, to a different extent. Consequently, mitochondrial protective agents may have major benefits for arthritis patients. Based on our current study, we recommend focusing on respiratory complex I in rheumatoid arthritis research.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms23147553</identifier><identifier>PMID: 35886901</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Arthritis ; Biomedical materials ; Body mass index ; Cartilage ; Cytochrome ; Cytochrome c ; Disease ; Electron transport chain ; Hydrogen peroxide ; Injuries ; Mitochondria ; Osteoarthritis ; Pathogenesis ; Patients ; Proteins ; Respiration ; Respirometry ; Rheumatoid arthritis ; Rheumatoid synovitis ; Surgery</subject><ispartof>International journal of molecular sciences, 2022-07, Vol.23 (14), p.7553</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-2488919a2eddf942dee032957b8872f34dfdb2a690d173907fcbe629c51d96fc3</citedby><cites>FETCH-LOGICAL-c389t-2488919a2eddf942dee032957b8872f34dfdb2a690d173907fcbe629c51d96fc3</cites><orcidid>0000-0001-5713-8471 ; 0000-0003-3700-5668 ; 0000-0002-4746-9792 ; 0000-0002-5628-9355 ; 0000-0001-8837-2375</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319158/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319158/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Jávor, Péter</creatorcontrib><creatorcontrib>Mácsai, Attila</creatorcontrib><creatorcontrib>Butt, Edina</creatorcontrib><creatorcontrib>Baráth, Bálint</creatorcontrib><creatorcontrib>Jász, Dávid Kurszán</creatorcontrib><creatorcontrib>Horváth, Tamara</creatorcontrib><creatorcontrib>Baráth, Bence</creatorcontrib><creatorcontrib>Csonka, Ákos</creatorcontrib><creatorcontrib>Török, László</creatorcontrib><creatorcontrib>Varga, Endre</creatorcontrib><creatorcontrib>Hartmann, Petra</creatorcontrib><title>Mitochondrial Dysfunction Affects the Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis Differently</title><title>International journal of molecular sciences</title><description>There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison of synovial mitochondrial derangements in these main arthritis forms is missing. A prospective clinical study was conducted on adult patients undergoing knee surgery. Patients were allocated into RA and OA groups based on disease-specific clinical scores, while patients without arthritis served as controls. Synovial samples were subjected to high-resolution respirometry to analyze mitochondrial functions. From the total of 814 patients, 109 cases were enrolled into the study (24 RA, 47 OA, and 38 control patients) between 1 September 2019 and 31 December 2021. The decrease in complex I-linked respiration and dyscoupling of mitochondria were characteristics of RA patients, while both arthritis groups displayed reduced OxPhos activity compared to the control group. However, no significant difference was found in complex II-related activity between the OA and RA groups. The cytochrome C release and H2O2 formation were increased in both arthritis groups. Mitochondrial dysfunction was present in both arthritis groups; however, to a different extent. Consequently, mitochondrial protective agents may have major benefits for arthritis patients. Based on our current study, we recommend focusing on respiratory complex I in rheumatoid arthritis research.</description><subject>Arthritis</subject><subject>Biomedical materials</subject><subject>Body mass index</subject><subject>Cartilage</subject><subject>Cytochrome</subject><subject>Cytochrome c</subject><subject>Disease</subject><subject>Electron transport chain</subject><subject>Hydrogen peroxide</subject><subject>Injuries</subject><subject>Mitochondria</subject><subject>Osteoarthritis</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Proteins</subject><subject>Respiration</subject><subject>Respirometry</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid synovitis</subject><subject>Surgery</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkclOHDEQhi2UKGy58QCWuOTAELvci32JNBpCgkQEguRsebzQHnXbxHaD5u1jBEKQU5WqvvprQ-iIklPGBPnqN1MGRpu-bdkO2qMNwIKQrv_wxt9F-zlvCAEGrfiEdlnLeScI3UP5ly9RDzGY5NWIz7bZzUEXHwNeOmd1ybgMFt9uQ3zw84Sjw9eqeBtq4tGXAd8Mdp5Uid7gZSpD8sVnrILBV7nYqF5DZ77KpVo3bg_RR6fGbD-_2AP05_z779XPxeXVj4vV8nKhGRdlAQ3nggoF1hgnGjDWEgai7dec9-BYY5xZg6p7GNrXS_ROr20HQrfUiM5pdoC-Pevez-vJGl2bJzXK--QnlbYyKi_fZ4If5F18kIJRQVteBb68CKT4d7a5yMlnbcdRBRvnLKETLYim411Fj_9DN3FOoa73RDUECACt1MkzpVPMOVn3Ogwl8umb8u032T80ipSR</recordid><startdate>20220707</startdate><enddate>20220707</enddate><creator>Jávor, Péter</creator><creator>Mácsai, Attila</creator><creator>Butt, Edina</creator><creator>Baráth, Bálint</creator><creator>Jász, Dávid Kurszán</creator><creator>Horváth, Tamara</creator><creator>Baráth, Bence</creator><creator>Csonka, Ákos</creator><creator>Török, László</creator><creator>Varga, Endre</creator><creator>Hartmann, Petra</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5713-8471</orcidid><orcidid>https://orcid.org/0000-0003-3700-5668</orcidid><orcidid>https://orcid.org/0000-0002-4746-9792</orcidid><orcidid>https://orcid.org/0000-0002-5628-9355</orcidid><orcidid>https://orcid.org/0000-0001-8837-2375</orcidid></search><sort><creationdate>20220707</creationdate><title>Mitochondrial Dysfunction Affects the Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis Differently</title><author>Jávor, Péter ; Mácsai, Attila ; Butt, Edina ; Baráth, Bálint ; Jász, Dávid Kurszán ; Horváth, Tamara ; Baráth, Bence ; Csonka, Ákos ; Török, László ; Varga, Endre ; Hartmann, Petra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-2488919a2eddf942dee032957b8872f34dfdb2a690d173907fcbe629c51d96fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arthritis</topic><topic>Biomedical materials</topic><topic>Body mass index</topic><topic>Cartilage</topic><topic>Cytochrome</topic><topic>Cytochrome c</topic><topic>Disease</topic><topic>Electron transport chain</topic><topic>Hydrogen peroxide</topic><topic>Injuries</topic><topic>Mitochondria</topic><topic>Osteoarthritis</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Proteins</topic><topic>Respiration</topic><topic>Respirometry</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid synovitis</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jávor, Péter</creatorcontrib><creatorcontrib>Mácsai, Attila</creatorcontrib><creatorcontrib>Butt, Edina</creatorcontrib><creatorcontrib>Baráth, Bálint</creatorcontrib><creatorcontrib>Jász, Dávid Kurszán</creatorcontrib><creatorcontrib>Horváth, Tamara</creatorcontrib><creatorcontrib>Baráth, Bence</creatorcontrib><creatorcontrib>Csonka, Ákos</creatorcontrib><creatorcontrib>Török, László</creatorcontrib><creatorcontrib>Varga, Endre</creatorcontrib><creatorcontrib>Hartmann, Petra</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jávor, Péter</au><au>Mácsai, Attila</au><au>Butt, Edina</au><au>Baráth, Bálint</au><au>Jász, Dávid Kurszán</au><au>Horváth, Tamara</au><au>Baráth, Bence</au><au>Csonka, Ákos</au><au>Török, László</au><au>Varga, Endre</au><au>Hartmann, Petra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondrial Dysfunction Affects the Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis Differently</atitle><jtitle>International journal of molecular sciences</jtitle><date>2022-07-07</date><risdate>2022</risdate><volume>23</volume><issue>14</issue><spage>7553</spage><pages>7553-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison of synovial mitochondrial derangements in these main arthritis forms is missing. A prospective clinical study was conducted on adult patients undergoing knee surgery. Patients were allocated into RA and OA groups based on disease-specific clinical scores, while patients without arthritis served as controls. Synovial samples were subjected to high-resolution respirometry to analyze mitochondrial functions. From the total of 814 patients, 109 cases were enrolled into the study (24 RA, 47 OA, and 38 control patients) between 1 September 2019 and 31 December 2021. The decrease in complex I-linked respiration and dyscoupling of mitochondria were characteristics of RA patients, while both arthritis groups displayed reduced OxPhos activity compared to the control group. However, no significant difference was found in complex II-related activity between the OA and RA groups. The cytochrome C release and H2O2 formation were increased in both arthritis groups. Mitochondrial dysfunction was present in both arthritis groups; however, to a different extent. Consequently, mitochondrial protective agents may have major benefits for arthritis patients. Based on our current study, we recommend focusing on respiratory complex I in rheumatoid arthritis research.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>35886901</pmid><doi>10.3390/ijms23147553</doi><orcidid>https://orcid.org/0000-0001-5713-8471</orcidid><orcidid>https://orcid.org/0000-0003-3700-5668</orcidid><orcidid>https://orcid.org/0000-0002-4746-9792</orcidid><orcidid>https://orcid.org/0000-0002-5628-9355</orcidid><orcidid>https://orcid.org/0000-0001-8837-2375</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2022-07, Vol.23 (14), p.7553 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9319158 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Arthritis Biomedical materials Body mass index Cartilage Cytochrome Cytochrome c Disease Electron transport chain Hydrogen peroxide Injuries Mitochondria Osteoarthritis Pathogenesis Patients Proteins Respiration Respirometry Rheumatoid arthritis Rheumatoid synovitis Surgery |
| title | Mitochondrial Dysfunction Affects the Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis Differently |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T13%3A52%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mitochondrial%20Dysfunction%20Affects%20the%20Synovium%20of%20Patients%20with%20Rheumatoid%20Arthritis%20and%20Osteoarthritis%20Differently&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=J%C3%A1vor,%20P%C3%A9ter&rft.date=2022-07-07&rft.volume=23&rft.issue=14&rft.spage=7553&rft.pages=7553-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms23147553&rft_dat=%3Cproquest_pubme%3E2694020221%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2694020221&rft_id=info:pmid/35886901&rfr_iscdi=true |