Store-Operated Ca2+ Entry Is Up-Regulated in Tumour-Infiltrating Lymphocytes from Metastatic Colorectal Cancer Patients

(1) Background: Store-operated Ca2+ entry (SOCE) drives the cytotoxic activity of cytotoxic T lymphocytes (CTLs) against cancer cells. However, SOCE can be enhanced in cancer cells due to an increase in the expression and/or function of its underlying molecular components, i.e., STIM1 and Orai1. Her...

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Veröffentlicht in:	Cancers 2022-07, Vol.14 (14), p.3312
Hauptverfasser:	Faris, Pawan, Rumolo, Agnese, Tapella, Laura, Tanzi, Matteo, Metallo, Alessia, Conca, Filippo, Negri, Sharon, Lefkimmiatis, Konstantinos, Pedrazzoli, Paolo, Lim, Dmitry, Montagna, Daniela, Moccia, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood & organ donations Blood banks Calcium channels Calcium influx Cancer Cancer therapies Cell death Cell therapy Colorectal cancer Colorectal carcinoma Cytokines Cytotoxicity Diacylglycerol kinase Effector cells Leukemia Liver Lymphocytes Lymphocytes T Metastases Metastasis Monoclonal antibodies Orai1 protein Patients Peripheral blood Protein kinase C STIM1 protein T cell receptors Tumors
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