Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens
The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. PDA was coated onto the surface of nephrite to improve antibacterial activity and to payload antibiotics. CIP...
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| Veröffentlicht in: | Materials 2022-07, Vol.15 (14), p.4823 |
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| creator | Kang, Min-Seung Moon, Kyung-Jin Lee, Ji-Eun Jeong, Young-IL |
| description | The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. PDA was coated onto the surface of nephrite to improve antibacterial activity and to payload antibiotics. CIP or LEVO was incorporated into the PDA layer on the surface of nephrite. Furthermore, CIP-incorporated/PDA-coated nephrite composites were embedded into the contact lenses. PDA-coated nephrite composites showed dull and smooth surfaces according to the dopamine concentration while nephrite itself has sharp surface morphology. CIP- or LEVO-loaded/PDA-coated nephrite composites also have dull and smooth surface properties. Nano and/or sub-micron clusters were observed in field emission-scanning electron microscopy (FE-SEM) observation, indicating that PDA nanoparticles were accumulated and coated onto the surface of nephrite. Furthermore, CIP- or LEVO-incorporated/PDA-coated nephrite composites showed the sustained release of CIP or LEVO in vitro and these properties contributed to the enhanced antibacterial activity of composites compared to nephrite or PDA-coated nephrite composites. CIP-incorporated/PDA-coated nephrite composites were embedded in the contact lenses and then, in an antibacterial study, they showed higher bactericidal effect against Staphylococcus aureus (S. aureus) compared to nephrite itself or PDA-coated nephrite composites. We suggest that CIP- or LEVO-loaded/PDA-coated nephrite composite-embedded contact lenses are a promising candidate for therapeutic application. |
| doi_str_mv | 10.3390/ma15144823 |
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PDA was coated onto the surface of nephrite to improve antibacterial activity and to payload antibiotics. CIP or LEVO was incorporated into the PDA layer on the surface of nephrite. Furthermore, CIP-incorporated/PDA-coated nephrite composites were embedded into the contact lenses. PDA-coated nephrite composites showed dull and smooth surfaces according to the dopamine concentration while nephrite itself has sharp surface morphology. CIP- or LEVO-loaded/PDA-coated nephrite composites also have dull and smooth surface properties. Nano and/or sub-micron clusters were observed in field emission-scanning electron microscopy (FE-SEM) observation, indicating that PDA nanoparticles were accumulated and coated onto the surface of nephrite. Furthermore, CIP- or LEVO-incorporated/PDA-coated nephrite composites showed the sustained release of CIP or LEVO in vitro and these properties contributed to the enhanced antibacterial activity of composites compared to nephrite or PDA-coated nephrite composites. CIP-incorporated/PDA-coated nephrite composites were embedded in the contact lenses and then, in an antibacterial study, they showed higher bactericidal effect against Staphylococcus aureus (S. aureus) compared to nephrite itself or PDA-coated nephrite composites. We suggest that CIP- or LEVO-loaded/PDA-coated nephrite composite-embedded contact lenses are a promising candidate for therapeutic application.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma15144823</identifier><identifier>PMID: 35888290</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Antibiotics ; Bacteria ; Biocompatibility ; By products ; Composite materials ; Contact lenses ; Dopamine ; Drug resistance ; Field emission microscopy ; Free radicals ; Gram-negative bacteria ; Gram-positive bacteria ; Hydrogels ; Medical equipment ; Morphology ; Nanoparticles ; Polymerization ; Polymers ; Surface properties ; Sustained release</subject><ispartof>Materials, 2022-07, Vol.15 (14), p.4823</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-b363d91c36172904558b13d009bd2d2e8c3881d544b0d9dea70361c1bce463613</citedby><cites>FETCH-LOGICAL-c383t-b363d91c36172904558b13d009bd2d2e8c3881d544b0d9dea70361c1bce463613</cites><orcidid>0000-0002-9832-4331</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315558/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315558/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Kang, Min-Seung</creatorcontrib><creatorcontrib>Moon, Kyung-Jin</creatorcontrib><creatorcontrib>Lee, Ji-Eun</creatorcontrib><creatorcontrib>Jeong, Young-IL</creatorcontrib><title>Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens</title><title>Materials</title><description>The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. 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We suggest that CIP- or LEVO-loaded/PDA-coated nephrite composite-embedded contact lenses are a promising candidate for therapeutic application.</description><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Biocompatibility</subject><subject>By products</subject><subject>Composite materials</subject><subject>Contact lenses</subject><subject>Dopamine</subject><subject>Drug resistance</subject><subject>Field emission microscopy</subject><subject>Free radicals</subject><subject>Gram-negative bacteria</subject><subject>Gram-positive bacteria</subject><subject>Hydrogels</subject><subject>Medical equipment</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Surface properties</subject><subject>Sustained release</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU9r3DAQxUVpSUKaSz6BoJdScCpZsle6FBY3TQtLEkp7FrI0u1GQJVeSA3vuF4-2Cf03l3kwP968YRA6p-SCMUneT5p2lHPRshfohErZN1Ry_vIvfYzOcr4ntRijopVH6Jh1QlRFTtDPdShu1KZActrjtSnuwZU9jlv8a-Jicab5Ch50dmGHb6Pf2zjryQVohqgLWHwN811yBfAQpznmqjLexoTX8-yd0cXFgF3AH9Oyay79Ug4-QwylbsUbCPk1erXVPsPZcz9F3z9dfhs-N5ubqy_DetMYJlhpRtYzK6lhPV3V7LzrxEiZJUSOtrUtiIoJajvOR2KlBb0iFTV0NMD7qtgp-vDkOy_jBNZAKEl7NSc36bRXUTv17yS4O7WLD0oy2tVt1eDts0GKPxbIRU0uG_BeB4hLVm0vu1bI1YpX9M1_6H1cUqjnHShOOKWSVerdE2VSzDnB9ncYStThverPe9kjZNCXow</recordid><startdate>20220711</startdate><enddate>20220711</enddate><creator>Kang, Min-Seung</creator><creator>Moon, Kyung-Jin</creator><creator>Lee, Ji-Eun</creator><creator>Jeong, Young-IL</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9832-4331</orcidid></search><sort><creationdate>20220711</creationdate><title>Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens</title><author>Kang, Min-Seung ; Moon, Kyung-Jin ; Lee, Ji-Eun ; Jeong, Young-IL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-b363d91c36172904558b13d009bd2d2e8c3881d544b0d9dea70361c1bce463613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Biocompatibility</topic><topic>By products</topic><topic>Composite materials</topic><topic>Contact lenses</topic><topic>Dopamine</topic><topic>Drug resistance</topic><topic>Field emission microscopy</topic><topic>Free radicals</topic><topic>Gram-negative bacteria</topic><topic>Gram-positive bacteria</topic><topic>Hydrogels</topic><topic>Medical equipment</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Polymerization</topic><topic>Polymers</topic><topic>Surface properties</topic><topic>Sustained release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Min-Seung</creatorcontrib><creatorcontrib>Moon, Kyung-Jin</creatorcontrib><creatorcontrib>Lee, Ji-Eun</creatorcontrib><creatorcontrib>Jeong, Young-IL</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Min-Seung</au><au>Moon, Kyung-Jin</au><au>Lee, Ji-Eun</au><au>Jeong, Young-IL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens</atitle><jtitle>Materials</jtitle><date>2022-07-11</date><risdate>2022</risdate><volume>15</volume><issue>14</issue><spage>4823</spage><pages>4823-</pages><issn>1996-1944</issn><eissn>1996-1944</eissn><abstract>The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. 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Furthermore, CIP- or LEVO-incorporated/PDA-coated nephrite composites showed the sustained release of CIP or LEVO in vitro and these properties contributed to the enhanced antibacterial activity of composites compared to nephrite or PDA-coated nephrite composites. CIP-incorporated/PDA-coated nephrite composites were embedded in the contact lenses and then, in an antibacterial study, they showed higher bactericidal effect against Staphylococcus aureus (S. aureus) compared to nephrite itself or PDA-coated nephrite composites. We suggest that CIP- or LEVO-loaded/PDA-coated nephrite composite-embedded contact lenses are a promising candidate for therapeutic application.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>35888290</pmid><doi>10.3390/ma15144823</doi><orcidid>https://orcid.org/0000-0002-9832-4331</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antibiotics Bacteria Biocompatibility By products Composite materials Contact lenses Dopamine Drug resistance Field emission microscopy Free radicals Gram-negative bacteria Gram-positive bacteria Hydrogels Medical equipment Morphology Nanoparticles Polymerization Polymers Surface properties Sustained release |
| title | Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens |
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