Disrupting Transcription and Folate Biosynthesis Leads to Synergistic Suppression of Escherichia coli Growth

The use of synergistic antibiotic combinations has emerged as a viable approach to contain the rapid spread of antibiotic‐resistant pathogens. Here we report the discovery of a new strongly synergistic pair – microcin J25 and sulfamonomethoxine. The former is a lasso peptide that inhibits the functi...

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