Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease

New conjugates of tacrine and salicylamide with alkylene spacers were synthesized and evaluated as potential multifunctional agents for Alzheimer's disease (AD). The compounds exhibited high acetylcholinesterase (AChE, IC50 to 0.224 μM) and butyrylcholinesterase (BChE, IC50 to 0.0104 μM) inhibi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ChemMedChem 2022-05, Vol.17 (10), p.e202200080-n/a
Hauptverfasser:	Grishchenko, Maria V., Makhaeva, Galina F., Burgart, Yanina V., Rudakova, Elena V., Boltneva, Natalia P., Kovaleva, Nadezhda V., Serebryakova, Olga G., Lushchekina, Sofya V., Astakhova, Tatiana Y., Zhilina, Ekaterina F., Shchegolkov, Evgeny V., Richardson, Rudy J., Saloutin, Victor I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid Amyloid beta-Peptides anti-AD multifunctional agents Butyrylcholinesterase - metabolism Carboxylesterase Chelation cholinesterase inhibitors Cholinesterase Inhibitors - chemistry Conjugates Copper Humans Inhibitors Iodides Iron Lead compounds Molecular docking Molecular Docking Simulation Neurodegenerative diseases Neuroprotective Agents - pharmacology Propidium iodide salicylamide Salicylamides - therapeutic use Scavenging Structure-Activity Relationship Tacrine Tacrine - chemistry Zinc
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!