Effects of Empagliflozin on Symptoms, Physical Limitations, and Quality of Life in Patients Hospitalized for Acute Heart Failure: Results From the EMPULSE Trial
Patients hospitalized for acute heart failure experience poor health status, including a high burden of symptoms and physical limitations, and poor quality of life. SGLT2 (sodium-glucose cotransporter 2) inhibitors improve health status in chronic heart failure, but their effect on these outcomes in...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2022-07, Vol.146 (4), p.279-288 |
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| creator | Kosiborod, Mikhail N Angermann, Christiane E Collins, Sean P Teerlink, John R Ponikowski, Piotr Biegus, Jan Comin-Colet, Josep Ferreira, João Pedro Mentz, Robert J Nassif, Michael E Psotka, Mitchell A Tromp, Jasper Brueckmann, Martina Blatchford, Jonathan P Salsali, Afshin Voors, Adriaan A |
| description | Patients hospitalized for acute heart failure experience poor health status, including a high burden of symptoms and physical limitations, and poor quality of life. SGLT2 (sodium-glucose cotransporter 2) inhibitors improve health status in chronic heart failure, but their effect on these outcomes in acute heart failure is not well characterized. We investigated the effects of the SGLT2 inhibitor empagliflozin on symptoms, physical limitations, and quality of life, using the Kansas City Cardiomyopathy Questionnaire (KCCQ) in the EMPULSE trial (Empagliflozin in Patients Hospitalized With Acute Heart Failure Who Have Been Stabilized).
Patients hospitalized for acute heart failure were randomized to empagliflozin 10 mg daily or placebo for 90 days. The KCCQ was assessed at randomization and 15, 30, and 90 days. The effects of empagliflozin on the primary end point of clinical benefit (hierarchical composite of all-cause death, heart failure events, and a 5-point or greater difference in KCCQ Total Symptom Score [TSS] change from baseline to 90 days) were examined post hoc across the tertiles of baseline KCCQ-TSS. In prespecified analyses, changes (randomization to day 90) in KCCQ domains, including TSS, physical limitations, quality of life, clinical summary, and overall summary scores were evaluated using a repeated measures model.
In total, 530 patients were randomized (265 each arm). Baseline KCCQ-TSS was low overall (mean [SD], 40.8 [24.0] points). Empagliflozin-treated patients experienced greater clinical benefit across the range of KCCQ-TSS, with no treatment effect heterogeneity (win ratio [95% CIs] from lowest to highest tertile: 1.49 [1.01-2.20], 1.37 [0.94-1.99], and 1.48 [1.00-2.20], respectively;
for interaction=0.94). Beneficial effects of empagliflozin on health status were observed as early as 15 days and persisted through 90 days, at which point empagliflozin-treated patients experienced a greater improvement in KCCQ TSS, physical limitations, quality of life, clinical summary, and overall summary (placebo-adjusted mean differences [95% CI]: 4.45 [95% CI, 0.32-8.59],
=0.03; 4.80 [95% CI, 0.00-9.61],
=0.05; 4.66 [95% CI, 0.32-9.01],
=0.04; 4.85 [95% CI, 0.77-8.92],
=0.02; and 4.40 points [95% CI, 0.33-8.48],
=0.03, respectively).
Initiation of empagliflozin in patients hospitalized for acute heart failure produced clinical benefit regardless of the degree of symptomatic impairment at baseline, and improved symptoms, physical limitations, and qu |
| doi_str_mv | 10.1161/CIRCULATIONAHA.122.059725 |
| format | Article |
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Patients hospitalized for acute heart failure were randomized to empagliflozin 10 mg daily or placebo for 90 days. The KCCQ was assessed at randomization and 15, 30, and 90 days. The effects of empagliflozin on the primary end point of clinical benefit (hierarchical composite of all-cause death, heart failure events, and a 5-point or greater difference in KCCQ Total Symptom Score [TSS] change from baseline to 90 days) were examined post hoc across the tertiles of baseline KCCQ-TSS. In prespecified analyses, changes (randomization to day 90) in KCCQ domains, including TSS, physical limitations, quality of life, clinical summary, and overall summary scores were evaluated using a repeated measures model.
In total, 530 patients were randomized (265 each arm). Baseline KCCQ-TSS was low overall (mean [SD], 40.8 [24.0] points). Empagliflozin-treated patients experienced greater clinical benefit across the range of KCCQ-TSS, with no treatment effect heterogeneity (win ratio [95% CIs] from lowest to highest tertile: 1.49 [1.01-2.20], 1.37 [0.94-1.99], and 1.48 [1.00-2.20], respectively;
for interaction=0.94). Beneficial effects of empagliflozin on health status were observed as early as 15 days and persisted through 90 days, at which point empagliflozin-treated patients experienced a greater improvement in KCCQ TSS, physical limitations, quality of life, clinical summary, and overall summary (placebo-adjusted mean differences [95% CI]: 4.45 [95% CI, 0.32-8.59],
=0.03; 4.80 [95% CI, 0.00-9.61],
=0.05; 4.66 [95% CI, 0.32-9.01],
=0.04; 4.85 [95% CI, 0.77-8.92],
=0.02; and 4.40 points [95% CI, 0.33-8.48],
=0.03, respectively).
Initiation of empagliflozin in patients hospitalized for acute heart failure produced clinical benefit regardless of the degree of symptomatic impairment at baseline, and improved symptoms, physical limitations, and quality of life, with benefits seen as early as 15 days and maintained through 90 days.
URL: https://www.
gov; Unique identifier: NCT0415775.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.122.059725</identifier><identifier>PMID: 35377706</identifier><language>eng</language><publisher>United States: American Heart Association</publisher><subject>Benzhydryl Compounds - adverse effects ; Cardiology and cardiovascular system ; Glucosides - adverse effects ; Heart Failure - diagnosis ; Heart Failure - drug therapy ; Human health and pathology ; Humans ; Life Sciences ; Original s ; Quality of Life ; Stroke Volume ; Treatment Outcome</subject><ispartof>Circulation (New York, N.Y.), 2022-07, Vol.146 (4), p.279-288</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2022 The Authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-a10e9cd4691242895741633d3e33591b4413ac5739e2fd8c92b2741ca15b52843</citedby><cites>FETCH-LOGICAL-c457t-a10e9cd4691242895741633d3e33591b4413ac5739e2fd8c92b2741ca15b52843</cites><orcidid>0000-0003-1215-0746 ; 0000-0001-9527-0852 ; 0000-0002-3750-9789 ; 0000-0002-3222-1719 ; 0000-0001-8780-720X ; 0000-0001-9977-7722 ; 0000-0002-3391-7064 ; 0000-0002-2304-6138 ; 0000-0001-7491-7637 ; 0000-0002-5417-4415 ; 0000-0001-9354-9657</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35377706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lorraine.fr/hal-03632187$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Kosiborod, Mikhail N</creatorcontrib><creatorcontrib>Angermann, Christiane E</creatorcontrib><creatorcontrib>Collins, Sean P</creatorcontrib><creatorcontrib>Teerlink, John R</creatorcontrib><creatorcontrib>Ponikowski, Piotr</creatorcontrib><creatorcontrib>Biegus, Jan</creatorcontrib><creatorcontrib>Comin-Colet, Josep</creatorcontrib><creatorcontrib>Ferreira, João Pedro</creatorcontrib><creatorcontrib>Mentz, Robert J</creatorcontrib><creatorcontrib>Nassif, Michael E</creatorcontrib><creatorcontrib>Psotka, Mitchell A</creatorcontrib><creatorcontrib>Tromp, Jasper</creatorcontrib><creatorcontrib>Brueckmann, Martina</creatorcontrib><creatorcontrib>Blatchford, Jonathan P</creatorcontrib><creatorcontrib>Salsali, Afshin</creatorcontrib><creatorcontrib>Voors, Adriaan A</creatorcontrib><title>Effects of Empagliflozin on Symptoms, Physical Limitations, and Quality of Life in Patients Hospitalized for Acute Heart Failure: Results From the EMPULSE Trial</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Patients hospitalized for acute heart failure experience poor health status, including a high burden of symptoms and physical limitations, and poor quality of life. SGLT2 (sodium-glucose cotransporter 2) inhibitors improve health status in chronic heart failure, but their effect on these outcomes in acute heart failure is not well characterized. We investigated the effects of the SGLT2 inhibitor empagliflozin on symptoms, physical limitations, and quality of life, using the Kansas City Cardiomyopathy Questionnaire (KCCQ) in the EMPULSE trial (Empagliflozin in Patients Hospitalized With Acute Heart Failure Who Have Been Stabilized).
Patients hospitalized for acute heart failure were randomized to empagliflozin 10 mg daily or placebo for 90 days. The KCCQ was assessed at randomization and 15, 30, and 90 days. The effects of empagliflozin on the primary end point of clinical benefit (hierarchical composite of all-cause death, heart failure events, and a 5-point or greater difference in KCCQ Total Symptom Score [TSS] change from baseline to 90 days) were examined post hoc across the tertiles of baseline KCCQ-TSS. In prespecified analyses, changes (randomization to day 90) in KCCQ domains, including TSS, physical limitations, quality of life, clinical summary, and overall summary scores were evaluated using a repeated measures model.
In total, 530 patients were randomized (265 each arm). Baseline KCCQ-TSS was low overall (mean [SD], 40.8 [24.0] points). Empagliflozin-treated patients experienced greater clinical benefit across the range of KCCQ-TSS, with no treatment effect heterogeneity (win ratio [95% CIs] from lowest to highest tertile: 1.49 [1.01-2.20], 1.37 [0.94-1.99], and 1.48 [1.00-2.20], respectively;
for interaction=0.94). Beneficial effects of empagliflozin on health status were observed as early as 15 days and persisted through 90 days, at which point empagliflozin-treated patients experienced a greater improvement in KCCQ TSS, physical limitations, quality of life, clinical summary, and overall summary (placebo-adjusted mean differences [95% CI]: 4.45 [95% CI, 0.32-8.59],
=0.03; 4.80 [95% CI, 0.00-9.61],
=0.05; 4.66 [95% CI, 0.32-9.01],
=0.04; 4.85 [95% CI, 0.77-8.92],
=0.02; and 4.40 points [95% CI, 0.33-8.48],
=0.03, respectively).
Initiation of empagliflozin in patients hospitalized for acute heart failure produced clinical benefit regardless of the degree of symptomatic impairment at baseline, and improved symptoms, physical limitations, and quality of life, with benefits seen as early as 15 days and maintained through 90 days.
URL: https://www.
gov; Unique identifier: NCT0415775.</description><subject>Benzhydryl Compounds - adverse effects</subject><subject>Cardiology and cardiovascular system</subject><subject>Glucosides - adverse effects</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - drug therapy</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Original s</subject><subject>Quality of Life</subject><subject>Stroke Volume</subject><subject>Treatment Outcome</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1q2zAYhsXYWLNutzC0w0GdWX9WtIOBCU4d8NasTY6NIsuNhmwZyS6kV7NLrUK2su5I6Pve50XiAeATSucIZejLcn273FX5dn3zIy_zOcJ4njLBMXsFZohhmlBGxGswS9NUJJxgfAHehfArXjPC2VtwQRjhnKfZDPwu2larMUDXwqIb5L01rXWPpoeuh3fHbhhdF67g5nAMRkkLK9OZUY7G9XEq-wb-nKQ14_HEV6bVMJKbuNd97CxdGGLamkfdwNZ5mKtp1LDU0o9wJY2dvP4Kb3WYbEyvvOvgeNCw-L7ZVXcF3Hoj7XvwppU26A9_zkuwWxXbZZlUN9frZV4lijI-JhKlWqiGZgJhiheCcYoyQhqiCWEC7SlFRCrGidC4bRZK4D2OESUR2zO8oOQSfDv3DtO-042KH_DS1oM3nfTH2klTv9z05lDfu4daEIQoz2LB53PB4T-szKv6NEtJRjBa8AcUs-KcVd6F4HX7DKC0PimuXyquo-L6rDiyH_996DP51yl5AofXpSI</recordid><startdate>20220726</startdate><enddate>20220726</enddate><creator>Kosiborod, Mikhail N</creator><creator>Angermann, Christiane E</creator><creator>Collins, Sean P</creator><creator>Teerlink, John R</creator><creator>Ponikowski, Piotr</creator><creator>Biegus, Jan</creator><creator>Comin-Colet, Josep</creator><creator>Ferreira, João Pedro</creator><creator>Mentz, Robert J</creator><creator>Nassif, Michael E</creator><creator>Psotka, Mitchell A</creator><creator>Tromp, Jasper</creator><creator>Brueckmann, Martina</creator><creator>Blatchford, Jonathan P</creator><creator>Salsali, Afshin</creator><creator>Voors, Adriaan A</creator><general>American Heart Association</general><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1215-0746</orcidid><orcidid>https://orcid.org/0000-0001-9527-0852</orcidid><orcidid>https://orcid.org/0000-0002-3750-9789</orcidid><orcidid>https://orcid.org/0000-0002-3222-1719</orcidid><orcidid>https://orcid.org/0000-0001-8780-720X</orcidid><orcidid>https://orcid.org/0000-0001-9977-7722</orcidid><orcidid>https://orcid.org/0000-0002-3391-7064</orcidid><orcidid>https://orcid.org/0000-0002-2304-6138</orcidid><orcidid>https://orcid.org/0000-0001-7491-7637</orcidid><orcidid>https://orcid.org/0000-0002-5417-4415</orcidid><orcidid>https://orcid.org/0000-0001-9354-9657</orcidid></search><sort><creationdate>20220726</creationdate><title>Effects of Empagliflozin on Symptoms, Physical Limitations, and Quality of Life in Patients Hospitalized for Acute Heart Failure: Results From the EMPULSE Trial</title><author>Kosiborod, Mikhail N ; Angermann, Christiane E ; Collins, Sean P ; Teerlink, John R ; Ponikowski, Piotr ; Biegus, Jan ; Comin-Colet, Josep ; Ferreira, João Pedro ; Mentz, Robert J ; Nassif, Michael E ; Psotka, Mitchell A ; Tromp, Jasper ; Brueckmann, Martina ; Blatchford, Jonathan P ; Salsali, Afshin ; Voors, Adriaan A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-a10e9cd4691242895741633d3e33591b4413ac5739e2fd8c92b2741ca15b52843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Benzhydryl Compounds - adverse effects</topic><topic>Cardiology and cardiovascular system</topic><topic>Glucosides - adverse effects</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - drug therapy</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Original s</topic><topic>Quality of Life</topic><topic>Stroke Volume</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kosiborod, Mikhail N</creatorcontrib><creatorcontrib>Angermann, Christiane E</creatorcontrib><creatorcontrib>Collins, Sean P</creatorcontrib><creatorcontrib>Teerlink, John R</creatorcontrib><creatorcontrib>Ponikowski, Piotr</creatorcontrib><creatorcontrib>Biegus, Jan</creatorcontrib><creatorcontrib>Comin-Colet, Josep</creatorcontrib><creatorcontrib>Ferreira, João Pedro</creatorcontrib><creatorcontrib>Mentz, Robert J</creatorcontrib><creatorcontrib>Nassif, Michael E</creatorcontrib><creatorcontrib>Psotka, Mitchell A</creatorcontrib><creatorcontrib>Tromp, Jasper</creatorcontrib><creatorcontrib>Brueckmann, Martina</creatorcontrib><creatorcontrib>Blatchford, Jonathan P</creatorcontrib><creatorcontrib>Salsali, Afshin</creatorcontrib><creatorcontrib>Voors, Adriaan A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kosiborod, Mikhail N</au><au>Angermann, Christiane E</au><au>Collins, Sean P</au><au>Teerlink, John R</au><au>Ponikowski, Piotr</au><au>Biegus, Jan</au><au>Comin-Colet, Josep</au><au>Ferreira, João Pedro</au><au>Mentz, Robert J</au><au>Nassif, Michael E</au><au>Psotka, Mitchell A</au><au>Tromp, Jasper</au><au>Brueckmann, Martina</au><au>Blatchford, Jonathan P</au><au>Salsali, Afshin</au><au>Voors, Adriaan A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Empagliflozin on Symptoms, Physical Limitations, and Quality of Life in Patients Hospitalized for Acute Heart Failure: Results From the EMPULSE Trial</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2022-07-26</date><risdate>2022</risdate><volume>146</volume><issue>4</issue><spage>279</spage><epage>288</epage><pages>279-288</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>Patients hospitalized for acute heart failure experience poor health status, including a high burden of symptoms and physical limitations, and poor quality of life. SGLT2 (sodium-glucose cotransporter 2) inhibitors improve health status in chronic heart failure, but their effect on these outcomes in acute heart failure is not well characterized. We investigated the effects of the SGLT2 inhibitor empagliflozin on symptoms, physical limitations, and quality of life, using the Kansas City Cardiomyopathy Questionnaire (KCCQ) in the EMPULSE trial (Empagliflozin in Patients Hospitalized With Acute Heart Failure Who Have Been Stabilized).
Patients hospitalized for acute heart failure were randomized to empagliflozin 10 mg daily or placebo for 90 days. The KCCQ was assessed at randomization and 15, 30, and 90 days. The effects of empagliflozin on the primary end point of clinical benefit (hierarchical composite of all-cause death, heart failure events, and a 5-point or greater difference in KCCQ Total Symptom Score [TSS] change from baseline to 90 days) were examined post hoc across the tertiles of baseline KCCQ-TSS. In prespecified analyses, changes (randomization to day 90) in KCCQ domains, including TSS, physical limitations, quality of life, clinical summary, and overall summary scores were evaluated using a repeated measures model.
In total, 530 patients were randomized (265 each arm). Baseline KCCQ-TSS was low overall (mean [SD], 40.8 [24.0] points). Empagliflozin-treated patients experienced greater clinical benefit across the range of KCCQ-TSS, with no treatment effect heterogeneity (win ratio [95% CIs] from lowest to highest tertile: 1.49 [1.01-2.20], 1.37 [0.94-1.99], and 1.48 [1.00-2.20], respectively;
for interaction=0.94). Beneficial effects of empagliflozin on health status were observed as early as 15 days and persisted through 90 days, at which point empagliflozin-treated patients experienced a greater improvement in KCCQ TSS, physical limitations, quality of life, clinical summary, and overall summary (placebo-adjusted mean differences [95% CI]: 4.45 [95% CI, 0.32-8.59],
=0.03; 4.80 [95% CI, 0.00-9.61],
=0.05; 4.66 [95% CI, 0.32-9.01],
=0.04; 4.85 [95% CI, 0.77-8.92],
=0.02; and 4.40 points [95% CI, 0.33-8.48],
=0.03, respectively).
Initiation of empagliflozin in patients hospitalized for acute heart failure produced clinical benefit regardless of the degree of symptomatic impairment at baseline, and improved symptoms, physical limitations, and quality of life, with benefits seen as early as 15 days and maintained through 90 days.
URL: https://www.
gov; Unique identifier: NCT0415775.</abstract><cop>United States</cop><pub>American Heart Association</pub><pmid>35377706</pmid><doi>10.1161/CIRCULATIONAHA.122.059725</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1215-0746</orcidid><orcidid>https://orcid.org/0000-0001-9527-0852</orcidid><orcidid>https://orcid.org/0000-0002-3750-9789</orcidid><orcidid>https://orcid.org/0000-0002-3222-1719</orcidid><orcidid>https://orcid.org/0000-0001-8780-720X</orcidid><orcidid>https://orcid.org/0000-0001-9977-7722</orcidid><orcidid>https://orcid.org/0000-0002-3391-7064</orcidid><orcidid>https://orcid.org/0000-0002-2304-6138</orcidid><orcidid>https://orcid.org/0000-0001-7491-7637</orcidid><orcidid>https://orcid.org/0000-0002-5417-4415</orcidid><orcidid>https://orcid.org/0000-0001-9354-9657</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2022-07, Vol.146 (4), p.279-288 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9311476 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Benzhydryl Compounds - adverse effects Cardiology and cardiovascular system Glucosides - adverse effects Heart Failure - diagnosis Heart Failure - drug therapy Human health and pathology Humans Life Sciences Original s Quality of Life Stroke Volume Treatment Outcome |
| title | Effects of Empagliflozin on Symptoms, Physical Limitations, and Quality of Life in Patients Hospitalized for Acute Heart Failure: Results From the EMPULSE Trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T11%3A57%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-hal_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Empagliflozin%20on%20Symptoms,%20Physical%20Limitations,%20and%20Quality%20of%20Life%20in%20Patients%20Hospitalized%20for%20Acute%20Heart%20Failure:%20Results%20From%20the%20EMPULSE%20Trial&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=Kosiborod,%20Mikhail%20N&rft.date=2022-07-26&rft.volume=146&rft.issue=4&rft.spage=279&rft.epage=288&rft.pages=279-288&rft.issn=0009-7322&rft.eissn=1524-4539&rft_id=info:doi/10.1161/CIRCULATIONAHA.122.059725&rft_dat=%3Chal_pubme%3Eoai_HAL_hal_03632187v1%3C/hal_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/35377706&rfr_iscdi=true |