Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches

Apoptosis is a highly regulated cellular process. Aberration in apoptosis is a common characteristic of various disorders. Therefore, proteins involved in apoptosis are prime targets in multiple therapies. Bcl‐xL is an antiapoptotic protein. Compared to other antiapoptotic proteins, the expression o...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2022-06, Vol.23 (12), p.e202100689-n/a
Hauptverfasser:	Negi, Arvind, Voisin‐Chiret, Anne Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Bcl-xL Bcl-xL inhibitors Cell permeability Chemoresistance Chimeras Conjugates drug conjugates IAP protein Inhibitors Leukemia Lymphoma on-target toxicity Pharmacology platelet toxicity Platelets Prodrugs PROTACs Proteins Proteolysis Review Reviews Selectivity SNIPERs Solid tumors Structural analysis Survival Toxicity Tumors Ubiquitin-protein ligase VHL protein
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