Computational Design, Synthesis, and Photochemistry of Cy7‐PPG, an Efficient NIR‐Activated Photolabile Protecting Group for Therapeutic Applications

Photolabile Protecting Groups (PPGs) are molecular tools used, for example, in photopharmacology for the activation of drugs with light, enabling spatiotemporal control over their potency. Yet, red‐shifting of PPG activation wavelengths into the NIR range, which penetrates the deepest in tissue, has...

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Veröffentlicht in:	Angewandte Chemie International Edition 2022-07, Vol.61 (27), p.e202201308-n/a
Hauptverfasser:	Alachouzos, Georgios, Schulte, Albert M., Mondal, Anirban, Szymanski, Wiktor, Feringa, Ben L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptivity Coloring Agents Computer applications Density Functional Theory Dyes Molecular orbitals NIR Light Oxygen Photochemistry Photolabile Protecting Groups Photopharmacology Protecting groups Synthesis Therapeutic applications Wavelengths
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