Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor

Objective The formation of 24S‐hydroxycholesterol is a brain‐specific mechanism of cholesterol catabolism catalyzed by cholesterol 24‐hydroxylase (CYP46A1, also known as CH24H). CH24H has been implicated in various biological mechanisms, whereas pharmacological lowering of 24S‐hydroxycholesterol has...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2022-06, Vol.63 (6), p.1580-1590
Hauptverfasser:	Nishi, Toshiya, Metcalf, Cameron S., Fujimoto, Shinji, Hasegawa, Shigeo, Miyamoto, Maki, Sunahara, Eiji, Watanabe, Sayuri, Kondo, Shinichi, White, H. Steve
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Animal models anticonvulsants Auditory stimuli Cholesterol cholesterol 24‐hydroxylase Convulsions & seizures Cornea CYP46A1 Electroconvulsive therapy Encephalopathy Epilepsy Hydroxylase Kindling Pharmacodynamics Pharmacokinetics Phenotypes Seizures soticlestat
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