Stereodivergent atom-transfer radical cyclization by engineered cytochromes P450

Naturally occurring enzymes can be a source of unnatural reactivity that can be molded by directed evolution to generate efficient biocatalysts with valuable activities. Owing to the lack of exploitable stereocontrol elements in synthetic systems, steering the absolute and relative stereochemistry o...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-12, Vol.374 (6575), p.1612-1616
Hauptverfasser:	Zhou, Qi, Chin, Michael, Fu, Yue, Liu, Peng, Yang, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Asymmetry Biocatalysis Biocatalysts Catalysis Catalysts Chemical reactions Chemistry Techniques, Synthetic Cofactors Cyclization Cytochrome Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Cytochromes Cytochromes P450 Directed evolution Directed Molecular Evolution Enantiomers Evolution Free Radicals Functional groups Heme Intermediates Molecular Structure Organic Chemistry Oxidation-Reduction Protein Engineering Radicals Redox properties Steering Stereochemistry Stereoisomerism Stereoselectivity Substrates Transition metals
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