Clinical Profile of SARS-CoV-2-Infected Neonates
BackgroundThere are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2.ObjectivesThis study investigates the mother-to-child transmission rate and...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-06, Vol.14 (6), p.e26298-e26298 |
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| creator | Kulkarni, Rajesh K Valvi, Chhaya Dawre, Rahul Rajput, Uday Nagpal, Rema Deshmukh, Isha Kamath, Pragathi Harwani, Richa Srinivasarangan, Ramya Sonteke, Somendra R, Apoorva Kamble, Savita Naik, Shilpa Bhosale, Ramesh Waghmare, Rakeesh Modi, Deepak Gajbhiye, Rahul Kinikar, Aarti A |
| description | BackgroundThere are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2.ObjectivesThis study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns.MethodsData on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma.ResultsA total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts.ConclusionsA proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms. |
| doi_str_mv | 10.7759/cureus.26298 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9308998</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2696787470</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-a98078df21203c9aa6264a0181af9bd41a796cfc0a9dc68ac15310a90099007e3</originalsourceid><addsrcrecordid>eNpdkU1LAzEQhoMottTe_AELXjy4dZLs5uMilMWPQlGx6jWk2US3bDc12RX8966tiHoYZoZ5GOadF6FjDBPOc3luumC7OCGMSLGHhgQzkQossv1f9QCNY1wBAAZOgMMhGtBcSEEZGSIo6qqpjK6T--BdVdvEu2QxfVikhX9OSTprnDWtLZNb6xvd2niEDpyuox1_5xF6urp8LG7S-d31rJjOU0OxbFMtBXBROoIJUCO1ZoRlGrDA2sllmWHNJTPOgJalYUIbnFPcNwCyD27pCF3s9m665dqWxjZt0LXahGqtw4fyulJ_J031ql78u5IUhOzVjdDp94Lg3zobW7WuorF1rRvru6gIk6x_SZazHj35h658F5pe3pbigmcceupsR5ngYwzW_RyDQX25oXZuqK0b9BO81npf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2696787470</pqid></control><display><type>article</type><title>Clinical Profile of SARS-CoV-2-Infected Neonates</title><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Kulkarni, Rajesh K ; Valvi, Chhaya ; Dawre, Rahul ; Rajput, Uday ; Nagpal, Rema ; Deshmukh, Isha ; Kamath, Pragathi ; Harwani, Richa ; Srinivasarangan, Ramya ; Sonteke, Somendra ; R, Apoorva ; Kamble, Savita ; Naik, Shilpa ; Bhosale, Ramesh ; Waghmare, Rakeesh ; Modi, Deepak ; Gajbhiye, Rahul ; Kinikar, Aarti A</creator><creatorcontrib>Kulkarni, Rajesh K ; Valvi, Chhaya ; Dawre, Rahul ; Rajput, Uday ; Nagpal, Rema ; Deshmukh, Isha ; Kamath, Pragathi ; Harwani, Richa ; Srinivasarangan, Ramya ; Sonteke, Somendra ; R, Apoorva ; Kamble, Savita ; Naik, Shilpa ; Bhosale, Ramesh ; Waghmare, Rakeesh ; Modi, Deepak ; Gajbhiye, Rahul ; Kinikar, Aarti A</creatorcontrib><description>BackgroundThere are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2.ObjectivesThis study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns.MethodsData on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma.ResultsA total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts.ConclusionsA proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.26298</identifier><identifier>PMID: 35898362</identifier><language>eng</language><publisher>Palo Alto: Cureus Inc</publisher><subject>Coronaviruses ; COVID-19 ; Infectious Disease ; Newborn babies ; Pediatrics ; Premature birth ; Severe acute respiratory syndrome coronavirus 2 ; Womens health</subject><ispartof>Curēus (Palo Alto, CA), 2022-06, Vol.14 (6), p.e26298-e26298</ispartof><rights>Copyright © 2022, Kulkarni et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Kulkarni et al. 2022 Kulkarni et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-a98078df21203c9aa6264a0181af9bd41a796cfc0a9dc68ac15310a90099007e3</citedby><cites>FETCH-LOGICAL-c319t-a98078df21203c9aa6264a0181af9bd41a796cfc0a9dc68ac15310a90099007e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308998/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308998/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Kulkarni, Rajesh K</creatorcontrib><creatorcontrib>Valvi, Chhaya</creatorcontrib><creatorcontrib>Dawre, Rahul</creatorcontrib><creatorcontrib>Rajput, Uday</creatorcontrib><creatorcontrib>Nagpal, Rema</creatorcontrib><creatorcontrib>Deshmukh, Isha</creatorcontrib><creatorcontrib>Kamath, Pragathi</creatorcontrib><creatorcontrib>Harwani, Richa</creatorcontrib><creatorcontrib>Srinivasarangan, Ramya</creatorcontrib><creatorcontrib>Sonteke, Somendra</creatorcontrib><creatorcontrib>R, Apoorva</creatorcontrib><creatorcontrib>Kamble, Savita</creatorcontrib><creatorcontrib>Naik, Shilpa</creatorcontrib><creatorcontrib>Bhosale, Ramesh</creatorcontrib><creatorcontrib>Waghmare, Rakeesh</creatorcontrib><creatorcontrib>Modi, Deepak</creatorcontrib><creatorcontrib>Gajbhiye, Rahul</creatorcontrib><creatorcontrib>Kinikar, Aarti A</creatorcontrib><title>Clinical Profile of SARS-CoV-2-Infected Neonates</title><title>Curēus (Palo Alto, CA)</title><description>BackgroundThere are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2.ObjectivesThis study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns.MethodsData on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma.ResultsA total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts.ConclusionsA proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms.</description><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Infectious Disease</subject><subject>Newborn babies</subject><subject>Pediatrics</subject><subject>Premature birth</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Womens health</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkU1LAzEQhoMottTe_AELXjy4dZLs5uMilMWPQlGx6jWk2US3bDc12RX8966tiHoYZoZ5GOadF6FjDBPOc3luumC7OCGMSLGHhgQzkQossv1f9QCNY1wBAAZOgMMhGtBcSEEZGSIo6qqpjK6T--BdVdvEu2QxfVikhX9OSTprnDWtLZNb6xvd2niEDpyuox1_5xF6urp8LG7S-d31rJjOU0OxbFMtBXBROoIJUCO1ZoRlGrDA2sllmWHNJTPOgJalYUIbnFPcNwCyD27pCF3s9m665dqWxjZt0LXahGqtw4fyulJ_J031ql78u5IUhOzVjdDp94Lg3zobW7WuorF1rRvru6gIk6x_SZazHj35h658F5pe3pbigmcceupsR5ngYwzW_RyDQX25oXZuqK0b9BO81npf</recordid><startdate>20220624</startdate><enddate>20220624</enddate><creator>Kulkarni, Rajesh K</creator><creator>Valvi, Chhaya</creator><creator>Dawre, Rahul</creator><creator>Rajput, Uday</creator><creator>Nagpal, Rema</creator><creator>Deshmukh, Isha</creator><creator>Kamath, Pragathi</creator><creator>Harwani, Richa</creator><creator>Srinivasarangan, Ramya</creator><creator>Sonteke, Somendra</creator><creator>R, Apoorva</creator><creator>Kamble, Savita</creator><creator>Naik, Shilpa</creator><creator>Bhosale, Ramesh</creator><creator>Waghmare, Rakeesh</creator><creator>Modi, Deepak</creator><creator>Gajbhiye, Rahul</creator><creator>Kinikar, Aarti A</creator><general>Cureus Inc</general><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220624</creationdate><title>Clinical Profile of SARS-CoV-2-Infected Neonates</title><author>Kulkarni, Rajesh K ; Valvi, Chhaya ; Dawre, Rahul ; Rajput, Uday ; Nagpal, Rema ; Deshmukh, Isha ; Kamath, Pragathi ; Harwani, Richa ; Srinivasarangan, Ramya ; Sonteke, Somendra ; R, Apoorva ; Kamble, Savita ; Naik, Shilpa ; Bhosale, Ramesh ; Waghmare, Rakeesh ; Modi, Deepak ; Gajbhiye, Rahul ; Kinikar, Aarti A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-a98078df21203c9aa6264a0181af9bd41a796cfc0a9dc68ac15310a90099007e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Infectious Disease</topic><topic>Newborn babies</topic><topic>Pediatrics</topic><topic>Premature birth</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulkarni, Rajesh K</creatorcontrib><creatorcontrib>Valvi, Chhaya</creatorcontrib><creatorcontrib>Dawre, Rahul</creatorcontrib><creatorcontrib>Rajput, Uday</creatorcontrib><creatorcontrib>Nagpal, Rema</creatorcontrib><creatorcontrib>Deshmukh, Isha</creatorcontrib><creatorcontrib>Kamath, Pragathi</creatorcontrib><creatorcontrib>Harwani, Richa</creatorcontrib><creatorcontrib>Srinivasarangan, Ramya</creatorcontrib><creatorcontrib>Sonteke, Somendra</creatorcontrib><creatorcontrib>R, Apoorva</creatorcontrib><creatorcontrib>Kamble, Savita</creatorcontrib><creatorcontrib>Naik, Shilpa</creatorcontrib><creatorcontrib>Bhosale, Ramesh</creatorcontrib><creatorcontrib>Waghmare, Rakeesh</creatorcontrib><creatorcontrib>Modi, Deepak</creatorcontrib><creatorcontrib>Gajbhiye, Rahul</creatorcontrib><creatorcontrib>Kinikar, Aarti A</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulkarni, Rajesh K</au><au>Valvi, Chhaya</au><au>Dawre, Rahul</au><au>Rajput, Uday</au><au>Nagpal, Rema</au><au>Deshmukh, Isha</au><au>Kamath, Pragathi</au><au>Harwani, Richa</au><au>Srinivasarangan, Ramya</au><au>Sonteke, Somendra</au><au>R, Apoorva</au><au>Kamble, Savita</au><au>Naik, Shilpa</au><au>Bhosale, Ramesh</au><au>Waghmare, Rakeesh</au><au>Modi, Deepak</au><au>Gajbhiye, Rahul</au><au>Kinikar, Aarti A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Profile of SARS-CoV-2-Infected Neonates</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2022-06-24</date><risdate>2022</risdate><volume>14</volume><issue>6</issue><spage>e26298</spage><epage>e26298</epage><pages>e26298-e26298</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>BackgroundThere are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2.ObjectivesThis study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns.MethodsData on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma.ResultsA total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts.ConclusionsA proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms.</abstract><cop>Palo Alto</cop><pub>Cureus Inc</pub><pmid>35898362</pmid><doi>10.7759/cureus.26298</doi><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central; PubMed Central Open Access |
| subjects | Coronaviruses COVID-19 Infectious Disease Newborn babies Pediatrics Premature birth Severe acute respiratory syndrome coronavirus 2 Womens health |
| title | Clinical Profile of SARS-CoV-2-Infected Neonates |
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