Rigidity‐Activity Relationships of bisQPC Scaffolds against Pathogenic Bacteria

Biscationic quaternary phosphonium compounds (bisQPCs) represent a promising class of antimicrobials, displaying potent activity against both Gram‐negative and Gram‐positive bacteria. In this study, we explored the effects of structural rigidity on the antimicrobial activity of QPC structures bearin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ChemMedChem 2022-07, Vol.17 (14), p.e202200224-n/a
Hauptverfasser:	Spahr, Aaron C., Michaud, Marina E., Amoo, Lauren E., Sanchez, Christian A., Hogue, Cody E., Thierer, Laura M., Gau, Michael R., Wuest, William M., Minbiole, Kevin P. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Alkynes Amphiphiles Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial Antimicrobial activity Antimicrobial agents Bacteria Biological activity Disinfectants Gram-Negative Bacteria Gram-Positive Bacteria Iodides Isomerization Microbial Sensitivity Tests Phosphonium compounds Phosphorus QPCs Rigid structures Rigidity Salts Staphylococcus aureus Strains (organisms)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!