Targeted Delivery of DNA Topoisomerase Inhibitor SN38 to Intracranial Tumors of Glioblastoma Using Sub‐5 Ultrafine Iron Oxide Nanoparticles

Effectively delivering therapeutics for treating brain tumors is hindered by the physical and biological barriers in the brain. Even with the compromised blood–brain barrier and highly angiogenic blood–tumor barrier seen in glioblastoma (GBM), most drugs, including nanomaterial‐based formulations, h...

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Veröffentlicht in:	Advanced healthcare materials 2022-07, Vol.11 (14), p.e2102816-n/a
Hauptverfasser:	Li, Yuancheng, Xie, Manman, Jones, Joshua B., Zhang, Zhaobin, Wang, Zi, Dang, Tu, Wang, Xinyu, Lipowska, Malgorzata, Mao, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Blood-brain barrier Brain cancer Brain Neoplasms - drug therapy Brain tumors Camptothecin Cell Line, Tumor Cytotoxicity Deoxyribonucleic acid DNA DNA topoisomerase DNA topoisomerase inhibitors drug delivery Glioblastoma Glioblastoma - drug therapy Glucuronosyltransferase Inhibitors Integrins iron oxide nanoparticles Iron oxides Magnetic Iron Oxide Nanoparticles Mice Nanomaterials Nanoparticles Oligopeptides pH effects SN38 theranostics Topoisomerase Inhibitors Toxicity tumor integrin Tumors Ultrafines
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