Quantitative assessment of myelin density using [11C]MeDAS PET in patients with multiple sclerosis: a first-in-human study

Purpose Multiple sclerosis (MS) is a disease characterized by inflammatory demyelinated lesions. New treatment strategies are being developed to stimulate myelin repair. Quantitative myelin imaging could facilitate these developments. This first-in-man study aimed to evaluate [ 11 C]MeDAS as a PET t...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2022-08, Vol.49 (10), p.3492-3507
Hauptverfasser:	van der Weijden, Chris W. J., Meilof, Jan F., van der Hoorn, Anouk, Zhu, Junqing, Wu, Chunying, Wang, Yanming, Willemsen, Antoon T. M., Dierckx, Rudi A. J. O., Lammertsma, Adriaan A., de Vries, Erik F. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - diagnostic imaging Brain - pathology Cardiology Density Humans Imaging Lesions Magnetic resonance imaging Medical imaging Medicine Medicine & Public Health Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - pathology Myelin Myelin Sheath - pathology Neuroimaging Neurology Nuclear Medicine Oncology Original Original Article Orthopedics Patients Positron emission Positron emission tomography Positron-Emission Tomography - methods Radiology Substantia alba Tomography White Matter - diagnostic imaging White Matter - pathology
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