High prevalence of fatigue in patients with Takayasu arteritis: a case–control study in a Brazilian centre
Abstract Objectives Several studies have shown not only a high prevalence of fatigue but also a reduction in health-related quality of life (HRQoL) in patients with rheumatic diseases. Owing to insufficient research in this area, we aimed to assess the prevalence of fatigue and its contribution to i...
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| Veröffentlicht in: | Rheumatology advances in practice 2022, Vol.6 (2), p.rkac054 |
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| description | Abstract
Objectives
Several studies have shown not only a high prevalence of fatigue but also a reduction in health-related quality of life (HRQoL) in patients with rheumatic diseases. Owing to insufficient research in this area, we aimed to assess the prevalence of fatigue and its contribution to impairment of HRQoL in patients with Takayasu arteritis (TAK).
Methods
This single-centre case–control study included 53 TAK patients who were matched by age, BMI and sex with 100 healthy individuals. Aside from the patients’ general data, the following information was collected: disease activity, level of activities of daily living (HAQ), physical activity levels and chronic fatigue.
Results
The TAK patients and healthy individuals were comparable in terms of current age, BMI and sex distribution. The median disease duration of TAK was 13.0 (7.0–20.0) years, and 11 (20.8%) patients had active disease. Compared with healthy individuals, patients with TAK had a higher prevalence of fatigue and lower HAQ score, physical activity level and intensity, and physical and psychosocial domains of the modified fatigue impact scale (P |
| doi_str_mv | 10.1093/rap/rkac054 |
| format | Article |
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Objectives
Several studies have shown not only a high prevalence of fatigue but also a reduction in health-related quality of life (HRQoL) in patients with rheumatic diseases. Owing to insufficient research in this area, we aimed to assess the prevalence of fatigue and its contribution to impairment of HRQoL in patients with Takayasu arteritis (TAK).
Methods
This single-centre case–control study included 53 TAK patients who were matched by age, BMI and sex with 100 healthy individuals. Aside from the patients’ general data, the following information was collected: disease activity, level of activities of daily living (HAQ), physical activity levels and chronic fatigue.
Results
The TAK patients and healthy individuals were comparable in terms of current age, BMI and sex distribution. The median disease duration of TAK was 13.0 (7.0–20.0) years, and 11 (20.8%) patients had active disease. Compared with healthy individuals, patients with TAK had a higher prevalence of fatigue and lower HAQ score, physical activity level and intensity, and physical and psychosocial domains of the modified fatigue impact scale (P < 0.01). Moreover, TAK patients had increased fatigue rates compared with the healthy individuals (fatigue severity scale: odds ratio = 2.6; 95% CI = 1.2, 5.4; modified fatigue impact scale: odds ratio = 2.6; 95% CI = 1.2, 5.5). Fatigue was positively correlated with worsening HAQ, CRP levels, daily prednisone dose and disease activity, and negatively correlated with disease duration.
Conclusion
TAK patients have a higher prevalence of fatigue, which affects different aspects of the disease, including physical function. Thus, fatigue-focused treatments should also be considered in clinical practice.
Trial registration
The Brazilian Clinical Trials Registry (ReBEC), https://ensaiosclinicos.gov.br/, RBR-9n4z2hh.
Lay Summary
What does this mean for patients?
Takayasu arteritis is a systemic autoimmune disease that affects blood vessels and causes a variety of symptoms, including pain and fatigue. These symptoms are often overlooked by rheumatologists and health-care professionals. However, 60% of the patients evaluated in this study had fatigue, in addition to being ∼2.6 times more likely to have fatigue than the population without rheumatic disease. On a day-to-day basis, this represents an increase in the difficulty of performing simple tasks, such as taking care of their own home and maintaining self-care, and often makes it difficult for patients to have a social life. This work is focused on fatigue and demonstrates that patients’ common complaints cannot be seen as merely tiredness or laziness; we should understand this complaint as important and relevant to the lives of patients, even in patients with no disease activity. Patients should seek strategies to combat or prevent this symptom, such as physical activity, because this is a low-cost strategy.</description><identifier>ISSN: 2514-1775</identifier><identifier>EISSN: 2514-1775</identifier><identifier>DOI: 10.1093/rap/rkac054</identifier><identifier>PMID: 35891881</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Body mass index ; Care and treatment ; Chronic diseases ; Corticosteroids ; Exercise ; Fatigue ; Medical research ; Medicine, Experimental ; Original ; Physical fitness ; Prednisone ; Self-care, Health</subject><ispartof>Rheumatology advances in practice, 2022, Vol.6 (2), p.rkac054</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.</rights><rights>COPYRIGHT 2022 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-f4479bd9480790bea9c48f9cf5bcbb196fd9b8b719d4a1babd53936a4cee90133</citedby><cites>FETCH-LOGICAL-c479t-f4479bd9480790bea9c48f9cf5bcbb196fd9b8b719d4a1babd53936a4cee90133</cites><orcidid>0000-0002-6998-6723 ; 0000-0002-3723-5028 ; 0000-0002-3682-4517</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308454/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308454/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35891881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>dos Santos, Alexandre Moura</creatorcontrib><creatorcontrib>Misse, Rafael Giovani</creatorcontrib><creatorcontrib>Borges, Isabela Bruna Pires</creatorcontrib><creatorcontrib>Gomes da Silva, Sarah Luiza</creatorcontrib><creatorcontrib>Kim, Ana Woo Sook</creatorcontrib><creatorcontrib>Pereira, Rosa Maria R</creatorcontrib><creatorcontrib>Shinjo, Samuel Katsuyuki</creatorcontrib><title>High prevalence of fatigue in patients with Takayasu arteritis: a case–control study in a Brazilian centre</title><title>Rheumatology advances in practice</title><addtitle>Rheumatol Adv Pract</addtitle><description>Abstract
Objectives
Several studies have shown not only a high prevalence of fatigue but also a reduction in health-related quality of life (HRQoL) in patients with rheumatic diseases. Owing to insufficient research in this area, we aimed to assess the prevalence of fatigue and its contribution to impairment of HRQoL in patients with Takayasu arteritis (TAK).
Methods
This single-centre case–control study included 53 TAK patients who were matched by age, BMI and sex with 100 healthy individuals. Aside from the patients’ general data, the following information was collected: disease activity, level of activities of daily living (HAQ), physical activity levels and chronic fatigue.
Results
The TAK patients and healthy individuals were comparable in terms of current age, BMI and sex distribution. The median disease duration of TAK was 13.0 (7.0–20.0) years, and 11 (20.8%) patients had active disease. Compared with healthy individuals, patients with TAK had a higher prevalence of fatigue and lower HAQ score, physical activity level and intensity, and physical and psychosocial domains of the modified fatigue impact scale (P < 0.01). Moreover, TAK patients had increased fatigue rates compared with the healthy individuals (fatigue severity scale: odds ratio = 2.6; 95% CI = 1.2, 5.4; modified fatigue impact scale: odds ratio = 2.6; 95% CI = 1.2, 5.5). Fatigue was positively correlated with worsening HAQ, CRP levels, daily prednisone dose and disease activity, and negatively correlated with disease duration.
Conclusion
TAK patients have a higher prevalence of fatigue, which affects different aspects of the disease, including physical function. Thus, fatigue-focused treatments should also be considered in clinical practice.
Trial registration
The Brazilian Clinical Trials Registry (ReBEC), https://ensaiosclinicos.gov.br/, RBR-9n4z2hh.
Lay Summary
What does this mean for patients?
Takayasu arteritis is a systemic autoimmune disease that affects blood vessels and causes a variety of symptoms, including pain and fatigue. These symptoms are often overlooked by rheumatologists and health-care professionals. However, 60% of the patients evaluated in this study had fatigue, in addition to being ∼2.6 times more likely to have fatigue than the population without rheumatic disease. On a day-to-day basis, this represents an increase in the difficulty of performing simple tasks, such as taking care of their own home and maintaining self-care, and often makes it difficult for patients to have a social life. This work is focused on fatigue and demonstrates that patients’ common complaints cannot be seen as merely tiredness or laziness; we should understand this complaint as important and relevant to the lives of patients, even in patients with no disease activity. Patients should seek strategies to combat or prevent this symptom, such as physical activity, because this is a low-cost strategy.</description><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Chronic diseases</subject><subject>Corticosteroids</subject><subject>Exercise</subject><subject>Fatigue</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Original</subject><subject>Physical fitness</subject><subject>Prednisone</subject><subject>Self-care, Health</subject><issn>2514-1775</issn><issn>2514-1775</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kd9qFDEUxoMotqy98l4CggiybbLJ7CReCLX0j1Dwpl6Hk8zJbuzsZExmKuuV7-Ab9kma7a6lBZFcnEPyO1-S7yPkNWeHnGlxlKA_StfgWCWfkf1ZxeWU13X1_FG_Rw5y_s4YmzHNBOcvyZ6olOZK8X3SXoTFkvYJb6DFziGNnnoYwmJEGjralxa7IdOfYVjSK7iGNeSRQhowhSHkjxSog4y3v_-42A0ptjQPY7PezAL9nOBXaAN01BWRhK_ICw9txoNdnZBvZ6dXJxfTy6_nX06OL6dO1nqYelmKbbRUrNbMImgnldfOV9ZZy_XcN9oqW3PdSOAWbFMJLeYgHaJmXIgJ-bTV7Ue7wub-cmhNn8IK0tpECObpSReWZhFvjBZMyUoWgfc7gRR_jJgHswrZYdtCh3HMZjbX1UzNRfFzQt5u0UUx0ITOx6LoNrg5rmuhJK8VL9ThP6iyGlyF4hz6UPafDHzYDrgUc07oH17Pmdkkb0ryZpd8od88_vAD-zfnArzbAnHs_6t0Bz9CuiM</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>dos Santos, Alexandre Moura</creator><creator>Misse, Rafael Giovani</creator><creator>Borges, Isabela Bruna Pires</creator><creator>Gomes da Silva, Sarah Luiza</creator><creator>Kim, Ana Woo Sook</creator><creator>Pereira, Rosa Maria R</creator><creator>Shinjo, Samuel Katsuyuki</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6998-6723</orcidid><orcidid>https://orcid.org/0000-0002-3723-5028</orcidid><orcidid>https://orcid.org/0000-0002-3682-4517</orcidid></search><sort><creationdate>2022</creationdate><title>High prevalence of fatigue in patients with Takayasu arteritis: a case–control study in a Brazilian centre</title><author>dos Santos, Alexandre Moura ; Misse, Rafael Giovani ; Borges, Isabela Bruna Pires ; Gomes da Silva, Sarah Luiza ; Kim, Ana Woo Sook ; Pereira, Rosa Maria R ; Shinjo, Samuel Katsuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-f4479bd9480790bea9c48f9cf5bcbb196fd9b8b719d4a1babd53936a4cee90133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Body mass index</topic><topic>Care and treatment</topic><topic>Chronic diseases</topic><topic>Corticosteroids</topic><topic>Exercise</topic><topic>Fatigue</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Original</topic><topic>Physical fitness</topic><topic>Prednisone</topic><topic>Self-care, Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>dos Santos, Alexandre Moura</creatorcontrib><creatorcontrib>Misse, Rafael Giovani</creatorcontrib><creatorcontrib>Borges, Isabela Bruna Pires</creatorcontrib><creatorcontrib>Gomes da Silva, Sarah Luiza</creatorcontrib><creatorcontrib>Kim, Ana Woo Sook</creatorcontrib><creatorcontrib>Pereira, Rosa Maria R</creatorcontrib><creatorcontrib>Shinjo, Samuel Katsuyuki</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Rheumatology advances in practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>dos Santos, Alexandre Moura</au><au>Misse, Rafael Giovani</au><au>Borges, Isabela Bruna Pires</au><au>Gomes da Silva, Sarah Luiza</au><au>Kim, Ana Woo Sook</au><au>Pereira, Rosa Maria R</au><au>Shinjo, Samuel Katsuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of fatigue in patients with Takayasu arteritis: a case–control study in a Brazilian centre</atitle><jtitle>Rheumatology advances in practice</jtitle><addtitle>Rheumatol Adv Pract</addtitle><date>2022</date><risdate>2022</risdate><volume>6</volume><issue>2</issue><spage>rkac054</spage><pages>rkac054-</pages><issn>2514-1775</issn><eissn>2514-1775</eissn><abstract>Abstract
Objectives
Several studies have shown not only a high prevalence of fatigue but also a reduction in health-related quality of life (HRQoL) in patients with rheumatic diseases. Owing to insufficient research in this area, we aimed to assess the prevalence of fatigue and its contribution to impairment of HRQoL in patients with Takayasu arteritis (TAK).
Methods
This single-centre case–control study included 53 TAK patients who were matched by age, BMI and sex with 100 healthy individuals. Aside from the patients’ general data, the following information was collected: disease activity, level of activities of daily living (HAQ), physical activity levels and chronic fatigue.
Results
The TAK patients and healthy individuals were comparable in terms of current age, BMI and sex distribution. The median disease duration of TAK was 13.0 (7.0–20.0) years, and 11 (20.8%) patients had active disease. Compared with healthy individuals, patients with TAK had a higher prevalence of fatigue and lower HAQ score, physical activity level and intensity, and physical and psychosocial domains of the modified fatigue impact scale (P < 0.01). Moreover, TAK patients had increased fatigue rates compared with the healthy individuals (fatigue severity scale: odds ratio = 2.6; 95% CI = 1.2, 5.4; modified fatigue impact scale: odds ratio = 2.6; 95% CI = 1.2, 5.5). Fatigue was positively correlated with worsening HAQ, CRP levels, daily prednisone dose and disease activity, and negatively correlated with disease duration.
Conclusion
TAK patients have a higher prevalence of fatigue, which affects different aspects of the disease, including physical function. Thus, fatigue-focused treatments should also be considered in clinical practice.
Trial registration
The Brazilian Clinical Trials Registry (ReBEC), https://ensaiosclinicos.gov.br/, RBR-9n4z2hh.
Lay Summary
What does this mean for patients?
Takayasu arteritis is a systemic autoimmune disease that affects blood vessels and causes a variety of symptoms, including pain and fatigue. These symptoms are often overlooked by rheumatologists and health-care professionals. However, 60% of the patients evaluated in this study had fatigue, in addition to being ∼2.6 times more likely to have fatigue than the population without rheumatic disease. On a day-to-day basis, this represents an increase in the difficulty of performing simple tasks, such as taking care of their own home and maintaining self-care, and often makes it difficult for patients to have a social life. This work is focused on fatigue and demonstrates that patients’ common complaints cannot be seen as merely tiredness or laziness; we should understand this complaint as important and relevant to the lives of patients, even in patients with no disease activity. Patients should seek strategies to combat or prevent this symptom, such as physical activity, because this is a low-cost strategy.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>35891881</pmid><doi>10.1093/rap/rkac054</doi><orcidid>https://orcid.org/0000-0002-6998-6723</orcidid><orcidid>https://orcid.org/0000-0002-3723-5028</orcidid><orcidid>https://orcid.org/0000-0002-3682-4517</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Body mass index Care and treatment Chronic diseases Corticosteroids Exercise Fatigue Medical research Medicine, Experimental Original Physical fitness Prednisone Self-care, Health |
| title | High prevalence of fatigue in patients with Takayasu arteritis: a case–control study in a Brazilian centre |
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